Detailed information of TA system TA169002

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): rlegTA/AbiEii-AbiEi
• Location: 3928699..3930218
• Replicon: chromosome
• Accession: NZ_CP059581
• Organism: Xanthomonas oryzae pv. oryzae strain IXO98

Toxin (Protein)

• Gene name: rlegT
• Uniprot ID: A0A0K0GMB6
• Locus tag: IXO98_RS18410
• Protein ID: WP_011259680.1
• Coordinates: 3929295..3930218 (+)
• Length: 308 a.a.

Antitoxin (Protein)

• Gene name: rlegA
• Uniprot ID: A0A854CLN1
• Locus tag: IXO98_RS18405
• Protein ID: WP_011409027.1
• Coordinates: 3928699..3929298 (+)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IXO98_RS18370 (IXO98_018330)	3924367..3924903	-	537	WP_024743012.1	lipocalin family protein	-
IXO98_RS18380	3925280..3925654	-	375	WP_237384745.1	hypothetical protein	-
IXO98_RS18385	3925635..3925925	-	291	WP_011409031.1	hypothetical protein	-
IXO98_RS18390 (IXO98_018350)	3926424..3927455	+	1032	WP_263108693.1	IS630 family transposase	-
IXO98_RS18395 (IXO98_018355)	3927437..3928012	-	576	WP_080493559.1	BrxE family protein	-
IXO98_RS18400 (IXO98_018360)	3928044..3928316	-	273	WP_230455482.1	FaeA/PapI family transcriptional regulator	-
IXO98_RS18405 (IXO98_018365)	3928699..3929298	+	600	WP_011409027.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
IXO98_RS18410 (IXO98_018370)	3929295..3930218	+	924	WP_011259680.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
IXO98_RS18415	3930298..3930768	-	471	WP_228329666.1	helix-turn-helix domain-containing protein	-
IXO98_RS18420 (IXO98_018385)	3931234..3931476	+	243	WP_011259679.1	hypothetical protein	-
IXO98_RS18425 (IXO98_018390)	3931901..3932410	+	510	WP_011259678.1	hypothetical protein	-
IXO98_RS18430 (IXO98_018395)	3932427..3932959	-	533	Protein_3517	protein N-lysine methyltransferase family protein	-
IXO98_RS18435 (IXO98_018400)	3932979..3934355	-	1377	Protein_3518	IS5 family transposase	-
IXO98_RS18440 (IXO98_018405)	3934467..3934619	-	153	Protein_3519	SAM-dependent methyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (41-269)

Antitoxin

• Transcriptional regulator, AbiEi antitoxin (7-52)

Sequences

Toxin

Protein

• Length: 308 a.a.
• Molecular weight: 34114.16 Da
• Isoelectric Point: 5.4588

>T169002 WP_011259680.1 NZ_CP059581:3929295-3930218 [Xanthomonas oryzae pv. oryzae]
MNEPDKSRRTVAASVRARLLNKARAERLDFNLLLTRYALERVLYRLSVSEQQGQFLLKGALLFDIWFDIPHRPTHDADLL
GFGSTEIPHLEDLFRRISQIASDDGIVFQADSVKAAEIRKEANYAGVRVTMIGLLDGARCTVQIDIGFGDAVTPGPDNVQ
YPVILDGMPQPQLRVYPRYTVVAEKLEAMVKLGILNSRMKDYFDLWVLAGHSDFDGAVLATAIRATFECRGTAIPPGAPL
GLTDEFGLDEQKTKQWQAFLRKNTLEPMPLTTVIEALREFVLPVLAALAAGEGFDRQWRAGAGWDAA

Nucleotide

• Length: 924 bp

>T169002 NZ_CP076269:53929-54078 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGGTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTTACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22037.74 Da
• Isoelectric Point: 10.1240

>AT169002 WP_011409027.1 NZ_CP059581:3928699-3929298 [Xanthomonas oryzae pv. oryzae]
MDTTVDKLLELVRTRGLLRPHDLAPLGIPRVALTRAVRRGQLERVGRGLYGLVARPVSAHGTLAEVARRVPKGVVCLLSA
LRVHDLTTQAPFEVWLAIDNKAAAPKLDYPPLRLVRFSGPALSEGVEEHVVDGVPVHVTSVAKTVADCFKYRNKIGIDVA
LEALREAWVARRMTSDEIWHYAKIDRVANVMRPYLESLA

Nucleotide

• Length: 600 bp

>AT169002 NZ_CP076269:c53885-53824 [Escherichia coli]
TTAAGGTACTTCATGCAGGCCTCACGAGTTAATGGATTAACAAGTGGGGTCTTCGCATTTCT

Structures

Toxin

• AlphaFold DB: A0A0K0GMB6

Antitoxin

• AlphaFold DB: A0A854CLN1