Detailed information of TA system TA168992

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YoeB-YefM
• Location: 1723514..1724019
• Replicon: chromosome
• Accession: NZ_CP059571
• Organism: Neisseria bacilliformis strain DSM 23338

Toxin (Protein)

• Gene name: relE
• Uniprot ID: F2BF20
• Locus tag: H3L91_RS08470
• Protein ID: WP_007343332.1
• Coordinates: 1723514..1723771 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: F2BF21
• Locus tag: H3L91_RS08475
• Protein ID: WP_007343333.1
• Coordinates: 1723768..1724019 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H3L91_RS08450	1719334..1720602	-	1269	WP_007343328.1	glutamate-5-semialdehyde dehydrogenase	-
H3L91_RS08455	1720613..1721722	-	1110	WP_007343329.1	glutamate 5-kinase	-
H3L91_RS08460	1722227..1722682	-	456	WP_007343330.1	cytochrome c	-
H3L91_RS08465	1723003..1723440	-	438	WP_007343331.1	YiiD C-terminal domain-containing protein	-
H3L91_RS08470	1723514..1723771	-	258	WP_007343332.1	Txe/YoeB family addiction module toxin	Toxin
H3L91_RS08475	1723768..1724019	-	252	WP_007343333.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
H3L91_RS08480	1724187..1725473	-	1287	WP_007343334.1	N-acetylmuramoyl-L-alanine amidase	-
H3L91_RS08485	1725443..1725928	-	486	WP_040659026.1	tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (1-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (3-73)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 10398.84 Da
• Isoelectric Point: 8.4535

>T168992 WP_007343332.1 NZ_CP059571:c1723771-1723514 [Neisseria bacilliformis]
MMLHFTDDAWDDYLYWQQTDKAVLKRINQLIKDMQRHPFEGLGKPEALRHHLAGYYSRRINHEHRIVYKADDSGIWLIAL
RYHYQ

Nucleotide

• Length: 258 bp

>T168992 NZ_CP076268:c2267114-2266863 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATATAACTCCCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 8519.68 Da
• Isoelectric Point: 5.7550

>AT168992 WP_007343333.1 NZ_CP059571:c1724019-1723768 [Neisseria bacilliformis]
MYAVHASELRKNLAATLDRVADNAEPVLITRSGGAAAVLLDINEYNALAETAYLLASPANAARLAKGVADVAAGRTAVRG
LAE

Nucleotide

• Length: 252 bp

>AT168992 NZ_CP076268:c2266866-2266612 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Structures

Toxin

• AlphaFold DB: F2BF20

Antitoxin

• AlphaFold DB: F2BF21