Detailed information of TA system TA168991

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /BrnT(toxin)
• Location: 718864..719338
• Replicon: chromosome
• Accession: NZ_CP059571
• Organism: Neisseria bacilliformis strain DSM 23338

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: H3L91_RS03720
• Protein ID: WP_040658735.1
• Coordinates: 719069..719338 (-)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: F2BBQ6
• Locus tag: H3L91_RS03715
• Protein ID: WP_007342170.1
• Coordinates: 718864..719088 (-)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H3L91_RS03680	714581..714928	+	348	WP_007342163.1	hypothetical protein	-
H3L91_RS03685	714925..716112	+	1188	WP_007342164.1	baseplate J/gp47 family protein	-
H3L91_RS03690	716109..716741	+	633	WP_007342165.1	DUF2612 domain-containing protein	-
H3L91_RS03695	716745..717128	+	384	Protein_721	hypothetical protein	-
H3L91_RS03700	717453..718088	+	636	WP_182109908.1	phage tail protein	-
H3L91_RS03705	718241..718411	+	171	WP_182109873.1	hypothetical protein	-
H3L91_RS03710	718567..718830	+	264	WP_007342169.1	hypothetical protein	-
H3L91_RS03715	718864..719088	-	225	WP_007342170.1	CopG family transcriptional regulator	Antitoxin
H3L91_RS03720	719069..719338	-	270	WP_040658735.1	BrnT family toxin	Toxin
H3L91_RS03725	719671..719838	+	168	WP_007342172.1	hypothetical protein	-
H3L91_RS03730	719939..720208	+	270	WP_007342173.1	hypothetical protein	-
H3L91_RS03735	720201..720710	+	510	WP_007342174.1	lysozyme	-
H3L91_RS03740	720796..720963	+	168	WP_007342175.1	hypothetical protein	-
H3L91_RS03745	720990..721847	-	858	WP_182109875.1	Rha family transcriptional regulator	-
H3L91_RS03750	722451..722654	+	204	WP_007342180.1	hypothetical protein	-
H3L91_RS03755	722708..723178	+	471	WP_007342181.1	lysozyme	-
H3L91_RS03760	723270..723764	+	495	WP_007342182.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	674203..723764	49561

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (5-80)

Antitoxin

• CopG antitoxin (2-69)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10441.82 Da
• Isoelectric Point: 7.2014

>T168991 WP_040658735.1 NZ_CP059571:c719338-719069 [Neisseria bacilliformis]
IMFEFDPNKSASNLEKHGIDFITAQQLWQDDYRLAVPAKTQGEERFALIAKLNQKVWTAVYTERGGNIRIISVRRAREKE
EQLYEHYGI

Nucleotide

• Length: 270 bp

>T168991 NZ_CP076268:c2266866-2266612 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 8477.55 Da
• Isoelectric Point: 4.7377

>AT168991 WP_007342170.1 NZ_CP059571:c719088-718864 [Neisseria bacilliformis]
MNTTEFDRRFDDGEDIADLLDLSRAAREGLQSKRVNVDFPAWMVESLDRQAAHLGVSRQSLIKMWLSERLAQAV

Nucleotide

• Length: 225 bp

>AT168991 NZ_CP076268:c2267114-2266863 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATATAACTCCCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Structures

Antitoxin

• AlphaFold DB: F2BBQ6