Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /DUF1778(antitoxin)
Location 691745..692514 Replicon chromosome
Accession NZ_CP059571
Organism Neisseria bacilliformis strain DSM 23338

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag H3L91_RS03540 Protein ID WP_040659381.1
Coordinates 691745..692242 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag H3L91_RS03545 Protein ID WP_040658727.1
Coordinates 692239..692514 (-) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H3L91_RS03490 686880..687062 + 183 WP_007342123.1 hypothetical protein -
H3L91_RS03495 687064..687213 + 150 WP_007342124.1 hypothetical protein -
H3L91_RS03500 687197..687382 - 186 WP_007342125.1 hypothetical protein -
H3L91_RS03505 687548..687772 + 225 WP_154647187.1 helix-turn-helix domain-containing protein -
H3L91_RS03510 687769..688665 + 897 WP_007342127.1 helix-turn-helix domain-containing protein -
H3L91_RS03515 688665..689447 + 783 WP_007342128.1 ATP-binding protein -
H3L91_RS03520 689765..690250 + 486 WP_007342130.1 hypothetical protein -
H3L91_RS03525 690240..690845 + 606 WP_007342131.1 DUF1367 family protein -
H3L91_RS03530 690842..691141 + 300 WP_007342132.1 DUF1364 domain-containing protein -
H3L91_RS03535 691143..691667 + 525 WP_007342133.1 hypothetical protein -
H3L91_RS03540 691745..692242 - 498 WP_040659381.1 GNAT family N-acetyltransferase Toxin
H3L91_RS03545 692239..692514 - 276 WP_040658727.1 DUF1778 domain-containing protein Antitoxin
H3L91_RS03550 692646..693056 + 411 WP_040658729.1 hypothetical protein -
H3L91_RS03555 693341..694690 + 1350 WP_007342138.1 PBSX family phage terminase large subunit -
H3L91_RS03560 694687..696660 + 1974 WP_007342139.1 DUF1073 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 674203..723764 49561


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(39-143)

Antitoxin

Vibrio phage ICP1, Orf50

(2-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18313.98 Da        Isoelectric Point: 9.2845

>T168990 WP_040659381.1 NZ_CP059571:c692242-691745 [Neisseria bacilliformis]
VKTVPLDTAKHNRQGFDCGVEALNLFLQRTANQQAAKNHARTYVLEDEADGTRIAGFYTLTMIQFELSQIPPQLQKKHRP
VQAAALIARLAVDTAYQGKGFGGFLLHDALCRLYQAAYLVGFPVVFVDAKDGMADFYRRYGFADAAANRLYITVETIRQA
IAKTA

Download         Length: 498 bp

>T168990 NZ_CP076268:c2052720-2052617 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 9893.32 Da        Isoelectric Point: 8.0845

>AT168990 WP_040658727.1 NZ_CP059571:c692514-692239 [Neisseria bacilliformis]
MTAATHTRVTARIDPATQSLLNRAAEAAGIPTINAFVLGAAVEKAKAILQQEEIIRLNADSSLRLLDALENPPAPNRHLS
ELFRKHRSECP

Download         Length: 276 bp

>AT168990 NZ_CP076268:2052579-2052850 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References