Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2480723..2481351 Replicon chromosome
Accession NZ_CP059570
Organism Neisseria dentiae strain DSM 19151

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag H3L92_RS11610 Protein ID WP_085365256.1
Coordinates 2480723..2481112 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag H3L92_RS11615 Protein ID WP_085365255.1
Coordinates 2481109..2481351 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H3L92_RS11595 2476568..2477839 + 1272 WP_085365259.1 phosphoribosylamine--glycine ligase -
H3L92_RS11600 2478041..2478634 + 594 WP_085365258.1 L-threonylcarbamoyladenylate synthase -
H3L92_RS11605 2478838..2480670 - 1833 WP_085365257.1 hypothetical protein -
H3L92_RS11610 2480723..2481112 - 390 WP_085365256.1 type II toxin-antitoxin system VapC family toxin Toxin
H3L92_RS11615 2481109..2481351 - 243 WP_085365255.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
H3L92_RS11620 2481746..2483305 + 1560 WP_085365254.1 nitrate reductase subunit beta -
H3L92_RS11625 2483305..2483976 + 672 WP_085365253.1 nitrate reductase molybdenum cofactor assembly chaperone -
H3L92_RS11630 2483973..2484656 + 684 WP_085365252.1 respiratory nitrate reductase subunit gamma -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-121)

Antitoxin

SpoVT-AbrB domain

(7-42)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14607.66 Da        Isoelectric Point: 6.4841

>T168989 WP_085365256.1 NZ_CP059570:c2481112-2480723 [Neisseria dentiae]
MKYLLDTNAVIAILNRNTDFIQRLKQHTPADFALSAITWFELHYGAHKSQKAAENLAKLEKLAFNILPFSQQDAQTAGKI
RSDLAKQGTPIGSYDILIAAQALSNQLVLITHNVREFERVEGLWVEDWE

Download         Length: 390 bp

>T168989 NZ_CP076268:c1686164-1684842 [Escherichia coli]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCCAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CAGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCTAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTAACGTTATTACCCGAAAA
TGAAACCATAACGCGCCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGGCTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCTCTGGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCGCAGGAGAAGACAGCGCTG
CTTAGAATAGGCAATGACTGGTGCATTCCGAAAGGAATAACGCCGACGACGCACATCATTAAATTACCGATTGGCGAAAT
CAGGCAGCCCAATGCGACGCTCGATCTCAGCCAAAGCGTTGATAATGAGTATTACTGTCTGCTGCTGGCGAAAGAACTTG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAGGGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATACTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGTCAGACATTCGGTTTACCTTCATCTGTGAAATA
TGAATCAGATGGAGGCCCAGGCATCGCGCGGATCATGGCGTTTTTGATGGGGTCCAGCGAGGCGCTTCGCGATCGTTATG
ATTTTATGAAATTCCAGGTCTTCCAGTGGTTGATTGGCGCAACGGATGGCCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTCCTTGGCGGTACGGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTTTGGCGACAGCAAAGGTGCTGAGATTCCCGGAAGTGCAGATGCATGAAATCCTAAGTGACTTTGCCAGAATGATTCCG
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAACCAATGTGTT
GAGGTTGCATGGACGGTTAAGCCGAGAATACGGTAGTAAGTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9229.30 Da        Isoelectric Point: 4.2346

>AT168989 WP_085365255.1 NZ_CP059570:c2481351-2481109 [Neisseria dentiae]
MTTAKLFWNGNSQAVRLPKEFRFEGKEVKISKQGNQVIIEPLVTDWDWLDSLGEPDASFETAVNEIRVEAAQERDWSVFE

Download         Length: 243 bp

>AT168989 NZ_CP076268:c1686430-1686164 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTAGCGAATGCAATGAAACTGGTTCGCCAGCAAAATGGCTGGAC
GCAGAGCGAGCTGGCGAAAAAAATTGGCATTAAGCAGGCGACAATTTCCAATTTCGAAAACAACCCTGACAATACCACGC
TCACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACACTATGCGACACGAAAAATGCCTCGCCAGAATCA
ACAGAACAGCAAGATCTGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References