Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1425540..1426123 Replicon chromosome
Accession NZ_CP059570
Organism Neisseria dentiae strain DSM 19151

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag H3L92_RS06740 Protein ID WP_085365891.1
Coordinates 1425872..1426123 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag H3L92_RS06735 Protein ID WP_085365890.1
Coordinates 1425540..1425875 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H3L92_RS06715 1420879..1422189 + 1311 WP_115336332.1 50S ribosome-binding GTPase -
H3L92_RS06720 1422425..1423246 + 822 WP_085365888.1 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase -
H3L92_RS06725 1423833..1424447 - 615 WP_085365930.1 ABC transporter substrate-binding protein -
H3L92_RS06730 1424674..1425240 - 567 WP_115336368.1 hypothetical protein -
H3L92_RS06735 1425540..1425875 - 336 WP_085365890.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
H3L92_RS06740 1425872..1426123 - 252 WP_085365891.1 type II toxin-antitoxin system HicA family toxin Toxin
H3L92_RS06745 1427355..1429262 - 1908 WP_085365893.1 DUF927 domain-containing protein -
H3L92_RS06750 1429259..1430344 - 1086 WP_085365894.1 toprim domain-containing protein -
H3L92_RS06755 1430526..1430687 - 162 WP_158088147.1 hypothetical protein -
H3L92_RS06760 1430684..1430938 - 255 WP_085365895.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(22-74)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9308.70 Da        Isoelectric Point: 5.6882

>T168988 WP_085365891.1 NZ_CP059570:c1426123-1425872 [Neisseria dentiae]
ISEFLFEFTIIFSRPVSGGIKWADIEVLFVELGAEIQEREGSRVAVILFGQVKVFHRPHPSPDTDKGAVASVRKWLEENG
VKP

Download         Length: 252 bp

>T168988 NZ_CP076268:1588891-1589067 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12047.40 Da        Isoelectric Point: 4.8447

>AT168988 WP_085365890.1 NZ_CP059570:c1425875-1425540 [Neisseria dentiae]
MNNVMEINGHKAIIQYDPETELLRGEFVGLNGGADFYADNVADLHKEGEASLAVFLDVCKEKGIEPYKQYSGRFNVRVSP
ETHAAAAAAAAAQNISLNEWVNRAISQSAHA

Download         Length: 336 bp

>AT168988 NZ_CP076268:1589113-1589529 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
GCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCGTTACCTTCGCCATTAAATAGTCATGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTGACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References