Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1425540..1426123 Replicon chromosome
Accession NZ_CP059570
Organism Neisseria dentiae strain DSM 19151

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag H3L92_RS06740 Protein ID WP_085365891.1
Coordinates 1425872..1426123 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag H3L92_RS06735 Protein ID WP_085365890.1
Coordinates 1425540..1425875 (-) Length 112 a.a.

Genomic Context

H3L92_RS06715H3L92_RS06720H3L92_RS06725H3L92_RS06730H3L92_RS06735H3L92_RS06740H3L92_RS06745H3L92_RS06750H3L92_RS06755H3L92_RS06760
Location: 1420879..1422189 (1311 bp)
Type: Others
Protein ID: WP_115336332.1
Location: 1422425..1423246 (822 bp)
Type: Others
Protein ID: WP_085365888.1
Location: 1423833..1424447 (615 bp)
Type: Others
Protein ID: WP_085365930.1
Location: 1424674..1425240 (567 bp)
Type: Others
Protein ID: WP_115336368.1
Location: 1425540..1425875 (336 bp)
Type: Antitoxin
Protein ID: WP_085365890.1
Location: 1425872..1426123 (252 bp)
Type: Toxin
Protein ID: WP_085365891.1
Location: 1427355..1429262 (1908 bp)
Type: Others
Protein ID: WP_085365893.1
Location: 1429259..1430344 (1086 bp)
Type: Others
Protein ID: WP_085365894.1
Location: 1430526..1430687 (162 bp)
Type: Others
Protein ID: WP_158088147.1
Location: 1430684..1430938 (255 bp)
Type: Others
Protein ID: WP_085365895.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
H3L92_RS067151420879..1422189+1311WP_115336332.150S ribosome-binding GTPase-
H3L92_RS067201422425..1423246+822WP_085365888.1bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase-
H3L92_RS067251423833..1424447-615WP_085365930.1ABC transporter substrate-binding protein-
H3L92_RS067301424674..1425240-567WP_115336368.1hypothetical protein-
H3L92_RS067351425540..1425875-336WP_085365890.1type II toxin-antitoxin system HicB family antitoxinAntitoxin
H3L92_RS067401425872..1426123-252WP_085365891.1type II toxin-antitoxin system HicA family toxinToxin
H3L92_RS067451427355..1429262-1908WP_085365893.1DUF927 domain-containing protein-
H3L92_RS067501429259..1430344-1086WP_085365894.1toprim domain-containing protein-
H3L92_RS067551430526..1430687-162WP_158088147.1hypothetical protein-
H3L92_RS067601430684..1430938-255WP_085365895.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(22-74)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9308.70 Da        Isoelectric Point: 5.6882

>T168988 WP_085365891.1 NZ_CP059570:c1426123-1425872 [Neisseria dentiae]
ISEFLFEFTIIFSRPVSGGIKWADIEVLFVELGAEIQEREGSRVAVILFGQVKVFHRPHPSPDTDKGAVASVRKWLEENG
VKP

Download         Length: 252 bp

>T168988 NZ_CP076268:1588891-1589067 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12047.40 Da        Isoelectric Point: 4.8447

>AT168988 WP_085365890.1 NZ_CP059570:c1425875-1425540 [Neisseria dentiae]
MNNVMEINGHKAIIQYDPETELLRGEFVGLNGGADFYADNVADLHKEGEASLAVFLDVCKEKGIEPYKQYSGRFNVRVSP
ETHAAAAAAAAAQNISLNEWVNRAISQSAHA

Download         Length: 336 bp

>AT168988 NZ_CP076268:1589113-1589529 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
GCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCGTTACCTTCGCCATTAAATAGTCATGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTGACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References