Detailed information of TA system TA168987

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /GNAT-DUF1778
• Location: 1810643..1811435
• Replicon: chromosome
• Accession: NZ_CP059569
• Organism: Kingella oralis strain DSM 18271

Toxin (Protein)

• Gene name: -
• Uniprot ID: C4GHH2
• Locus tag: H3L93_RS09690
• Protein ID: WP_003793638.1
• Coordinates: 1810643..1811161 (-)
• Length: 173 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: H3L93_RS09695
• Protein ID: WP_040558274.1
• Coordinates: 1811151..1811435 (-)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H3L93_RS09650	1806332..1806574	-	243	WP_003793652.1	hypothetical protein	-
H3L93_RS09655	1806600..1807184	-	585	WP_003793651.1	hypothetical protein	-
H3L93_RS09660	1807370..1807750	-	381	WP_003793649.1	hypothetical protein	-
H3L93_RS09665	1807747..1807980	-	234	WP_003793648.1	hypothetical protein	-
H3L93_RS09670	1808353..1808814	+	462	WP_003793647.1	hypothetical protein	-
H3L93_RS09675	1808819..1809025	-	207	WP_040558068.1	hypothetical protein	-
H3L93_RS09680	1809878..1810177	+	300	WP_003793643.1	type II toxin-antitoxin system MqsR family toxin	-
H3L93_RS09685	1810183..1810581	+	399	WP_040558276.1	type II toxin-antitoxin system MqsA family antitoxin	-
H3L93_RS09690	1810643..1811161	-	519	WP_003793638.1	GNAT family N-acetyltransferase	Toxin
H3L93_RS09695	1811151..1811435	-	285	WP_040558274.1	DUF1778 domain-containing protein	Antitoxin
H3L93_RS09700	1811556..1812152	-	597	WP_003793634.1	helix-turn-helix domain-containing protein	-
H3L93_RS09705	1812278..1812478	+	201	WP_003793632.1	helix-turn-helix domain-containing protein	-
H3L93_RS09710	1812600..1813412	+	813	WP_003793630.1	hypothetical protein	-
H3L93_RS09715	1814409..1815164	+	756	WP_003793622.1	hypothetical protein	-
H3L93_RS09720	1815372..1815785	-	414	WP_003793618.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (48-153)

Antitoxin

• Vibrio phage ICP1, Orf50 (3-84)

Sequences

Toxin

Protein

• Length: 173 a.a.
• Molecular weight: 19039.89 Da
• Isoelectric Point: 8.0187

>T168987 WP_003793638.1 NZ_CP059569:c1811161-1810643 [Kingella oralis]
MNDNPAVVVLNKGVEPLNETHNRKGFDCGVPALNDFLQKFAGQKSNRNQAQTYVLSADDNETIIGYFTLTMTRFNWHEIV
GKKSKTVDTAALIARLAVDKRFTGQGVGLFLLRTALEKLIIANDILGVPIIVVDAKDGVSAFYETVGFQFLEQGSSRLFI
TMETILNSQKIK

Nucleotide

• Length: 519 bp

>T168987 NZ_CP076268:c1476545-1476351 [Escherichia coli]
TTGAGATATGACGATGTTAAACCATGTCCGTTTTGTGGTTGTCCATCAGTAACGGTGAAAGACATTTCAGGATATTACCG
GGCAAAATGCAACGGATGCGAATCCCGAACTGGCTATGGTGGAAGTGAAAAAGAAGCGCTCGAAAGATGGAATAAACGAA
CCACTGAAAATATTAATGGAGGCGTTCATGTATAA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10466.91 Da
• Isoelectric Point: 4.7063

>AT168987 WP_040558274.1 NZ_CP059569:c1811435-1811151 [Kingella oralis]
MTSTAPRITARIDVQTQDLLKEAAQLAGISSINSFVLQAALKEAKAIIAQEQTIQLSQEASLRLMDALNNPPEPNPKLRQ
LFQTNFDEVNVYER

Nucleotide

• Length: 285 bp

>AT168987 NZ_CP076268:1476174-1476352 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATTGTAGCGGTAATTTT

Structures

Toxin

• AlphaFold DB: C4GHH2