Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1697554..1698200 Replicon chromosome
Accession NZ_CP059569
Organism Kingella oralis strain DSM 18271

Toxin (Protein)


Gene name VapC1 Uniprot ID C4GHW7
Locus tag H3L93_RS09105 Protein ID WP_003793849.1
Coordinates 1697793..1698200 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name VapB1 Uniprot ID C4GHW8
Locus tag H3L93_RS09100 Protein ID WP_003793850.1
Coordinates 1697554..1697796 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H3L93_RS09075 1694011..1694313 - 303 WP_003793863.1 hypothetical protein -
H3L93_RS09080 1694420..1694755 - 336 WP_003793861.1 hypothetical protein -
H3L93_RS09085 1694867..1695208 - 342 WP_003793857.1 hypothetical protein -
H3L93_RS09090 1695277..1696029 - 753 WP_003793855.1 prolipoprotein diacylglyceryl transferase -
H3L93_RS09095 1696142..1697365 - 1224 WP_003793854.1 aspartate kinase -
H3L93_RS09100 1697554..1697796 + 243 WP_003793850.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
H3L93_RS09105 1697793..1698200 + 408 WP_003793849.1 PIN domain-containing protein Toxin
H3L93_RS09110 1698362..1699174 - 813 WP_003793847.1 CDP-diacylglycerol--serine O-phosphatidyltransferase -
H3L93_RS09115 1699335..1700144 - 810 WP_003793843.1 4-hydroxy-tetrahydrodipicolinate reductase -
H3L93_RS09120 1700155..1700538 - 384 WP_003793842.1 outer membrane protein assembly factor BamE -
H3L93_RS09125 1700696..1701121 + 426 WP_003793837.1 ferric iron uptake transcriptional regulator -
H3L93_RS09130 1701365..1701925 - 561 WP_003793834.1 elongation factor P -
H3L93_RS09135 1702194..1702913 + 720 WP_040558297.1 endonuclease/exonuclease/phosphatase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-125)

Antitoxin

SpoVT-AbrB domain

(6-46)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15243.62 Da        Isoelectric Point: 7.9026

>T168985 WP_003793849.1 NZ_CP059569:1697793-1698200 [Kingella oralis]
MMYMLDTNILIYIQKNNPPAVREKINRLPSHAKLCMSFVSYAELLSGAQGSRNPEKARENIARLVQIVSVLLPETPICEH
YARWRDALKRQGAMIGGNDLWIAAHALAADAVLVTHNTKEFAQIGDLKWEDWTAQ

Download         Length: 408 bp

>T168985 NZ_CP076268:c1338505-1338398 [Escherichia coli]
ATGACGCTCGCGAAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8797.78 Da        Isoelectric Point: 4.3417

>AT168985 WP_003793850.1 NZ_CP059569:1697554-1697796 [Kingella oralis]
MLTKIFQSGGSQAVRIPKDFRFNGDTVEIFRAENGDVVLRAPQSSQRGDALFAVLAQFDDDFIAGVAARDNEPPQERDAL

Download         Length: 243 bp

>AT168985 NZ_CP076268:1338558-1338619 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB C4GHW7

Antitoxin

Source ID Structure
AlphaFold DB C4GHW8

References