Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 2307065..2307651 Replicon chromosome
Accession NZ_CP059567
Organism Neisseria shayeganii strain DSM 22244

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag H3L94_RS11330 Protein ID WP_182123179.1
Coordinates 2307397..2307651 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag H3L94_RS11325 Protein ID WP_182122067.1
Coordinates 2307065..2307400 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H3L94_RS11305 2302584..2303438 - 855 WP_009120072.1 elongation factor Ts -
H3L94_RS11310 2303538..2304263 - 726 WP_009120073.1 30S ribosomal protein S2 -
H3L94_RS11315 2304574..2305089 - 516 WP_009120075.1 pantetheine-phosphate adenylyltransferase -
H3L94_RS11320 2305086..2306216 - 1131 WP_182122066.1 beta-ketoacyl-ACP synthase III -
H3L94_RS11325 2307065..2307400 - 336 WP_182122067.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
H3L94_RS11330 2307397..2307651 - 255 WP_182123179.1 type II toxin-antitoxin system HicA family toxin Toxin
H3L94_RS11335 2308056..2308397 - 342 WP_182122068.1 hypothetical protein -
H3L94_RS11340 2308772..2310682 - 1911 WP_182122069.1 DUF927 domain-containing protein -
H3L94_RS11345 2310679..2311737 - 1059 WP_182122070.1 toprim domain-containing protein -
H3L94_RS11350 2311734..2312051 - 318 WP_182122071.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-75)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9420.86 Da        Isoelectric Point: 10.6504

>T168982 WP_182123179.1 NZ_CP059567:c2307651-2307397 [Neisseria shayeganii]
MKKRHQRTLALIFSRPVSGGIKWADIESLFTELGAEIQEREGSRIAVVLFGQVKVFHRPHPSPDTDKGAVASVRKWLEDN
GVKP

Download         Length: 255 bp

>T168982 NZ_CP076268:c496883-496341 [Escherichia coli]
ATGGTCGACAAGCATGAAGAGATTACTCTGCCCATAGTCCTCTCCTGTAATTATCAGTCTGATATTACTTATCCTGGGCA
AAAACAGTTTGATTGCGGTAACCCTGTTATCGATAAATTTGTACGCGCATCGCTAAAGAAAAGTGTGCGTAATAGCGACT
GTGCGGCTAAAGCACTTATTGACAGACAAAGTGGTGAACTGATCGGCATCTGTACTTTTACGGCATATTCGCTGGAAAAA
CAACGCGTTTCTGGCGTCCTTCAGGGTTCACAACCTTCAGAAATTGGTGTTGTCAGATTAGTCATGTTGGGGGTAGCACG
GAAGTATCAAAAGCGGGGCTTTGGTCAGGACCTACTATGTGATTTTTTTGAACATGTAAAAATAATTCACCAGGCATTAC
CAATTAAAGGGGTTTATCTTGATGCTGACCCTGCCGCCATTAATTTTTATGCTCGTCTCGGCTTTGTTCAGCTTTCAGCG
ACACCAAATGCTTTTGGTGCTGTACCTATGTTTTTGGCGATTCAGCATATTCTCGCGGCTTAG

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 11967.40 Da        Isoelectric Point: 5.0746

>AT168982 WP_182122067.1 NZ_CP059567:c2307400-2307065 [Neisseria shayeganii]
MNNIMEINGHKAVIQYDPETELLRGEFIGLNGGADFYADNVADLHKEGAASLAIFLDVCKEKGIEPYKQYSGRFNVRVSP
ATHAAAVAAAAAQNISLNEWVSRAISQSAQS

Download         Length: 336 bp

>AT168982 NZ_CP076268:c497178-496867 [Escherichia coli]
ATGCCTGGAAAAACAGCCACTCTACCCGATGTCGATAAAACGCTGAAAAATGCGCGGGTCGAACTCAAAACTAGTCCCGA
CGCCAAAAACAAACTTCGTGAAGCTGCGCAAGCCGTTGGGGTAGATTTAAGCGCTTTTATTTTGAGCGCTGCTATGGAAC
GCGCCGAAAGTGTGCTTGATAACCAACGTCGCCGTGAGCTTTCGAATCAAAGCTGGGAACTGATGAACCAACTCATCGCT
GAACCTGCTCAACCGACGCTCGCCCTCAAGGCGTTAATGAAAAGGAAAAACAGCGATGGTCGACAAGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References