Detailed information of TA system TA168980

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): stbE-relB/ParE-YafN
• Location: 165857..166376
• Replicon: chromosome
• Accession: NZ_CP059567
• Organism: Neisseria shayeganii strain DSM 22244

Toxin (Protein)

• Gene name: stbE
• Uniprot ID: -
• Locus tag: H3L94_RS00750
• Protein ID: WP_182122264.1
• Coordinates: 166089..166376 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: G4CKR4
• Locus tag: H3L94_RS00745
• Protein ID: WP_009119890.1
• Coordinates: 165857..166099 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H3L94_RS00720	161454..162266	-	813	WP_182122262.1	inositol monophosphatase	-
H3L94_RS00725	162574..163065	+	492	WP_009119895.1	DUF456 family protein	-
H3L94_RS00730	163277..163690	+	414	WP_009119894.1	PTS mannose transporter subunit IIA	-
H3L94_RS00735	163684..163953	+	270	WP_009119893.1	HPr family phosphocarrier protein	-
H3L94_RS00740	163956..165707	+	1752	WP_182122263.1	phosphoenolpyruvate--protein phosphotransferase	-
H3L94_RS00745	165857..166099	+	243	WP_009119890.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
H3L94_RS00750	166089..166376	+	288	WP_182122264.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
H3L94_RS00755	166781..167221	+	441	WP_182122265.1	pilin	-
H3L94_RS00760	167299..167769	+	471	WP_182122266.1	pilin	-
H3L94_RS00765	167777..168517	+	741	WP_182122267.1	fimbrial protein	-
H3L94_RS00770	168600..169409	-	810	WP_182122268.1	cytochrome c biogenesis protein CcsA	-
H3L94_RS00775	169738..171099	+	1362	WP_182122269.1	signal recognition particle protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-83)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-74)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 10940.96 Da
• Isoelectric Point: 11.0229

>T168980 WP_182122264.1 NZ_CP059567:166089-166376 [Neisseria shayeganii]
MIYKLYFLPSAKREWDKLGGSIKRQFKSKLAERLKEPRIPSAALHNMPDCYTIKLRGAGYRLVYRVDGERITVTVLAIGK
RERLAVYRAAAKRAT

Nucleotide

• Length: 288 bp

>T168980 NZ_CP059567:166089-166376 [Neisseria shayeganii]
ATGATTTATAAACTCTATTTCCTGCCGTCGGCCAAGCGGGAGTGGGACAAACTGGGCGGCAGCATCAAGCGGCAATTCAA
ATCCAAACTGGCCGAACGTCTAAAAGAACCCCGTATCCCCTCTGCTGCCCTGCACAATATGCCGGACTGCTACACAATCA
AACTGCGCGGCGCAGGCTACCGTTTGGTTTATCGGGTAGATGGAGAGCGGATTACCGTAACCGTGCTGGCCATAGGCAAA
CGCGAACGGCTGGCGGTGTACCGTGCGGCAGCCAAAAGGGCTACCTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8910.94 Da
• Isoelectric Point: 4.1469

>AT168980 WP_009119890.1 NZ_CP059567:165857-166099 [Neisseria shayeganii]
MHTILADYTVSVTELKRNYAAIVAEADGAVAVLNHNKPESYLIPAARYEALMDYLEDLEDAETVRRRSNETGVEVALDDL

Nucleotide

• Length: 243 bp

>AT168980 NZ_CP059567:165857-166099 [Neisseria shayeganii]
ATGCACACCATTTTAGCCGACTACACCGTCAGCGTGACCGAATTGAAGCGCAATTACGCCGCCATCGTAGCCGAGGCCGA
CGGCGCAGTGGCCGTGTTGAACCACAACAAACCGGAATCCTACTTAATCCCCGCCGCCCGCTATGAAGCCCTCATGGATT
ATTTGGAAGATTTGGAAGATGCCGAAACCGTGCGCCGCCGCTCGAATGAAACAGGCGTAGAGGTGGCGTTGGATGATTTA
TAA

Structures

Antitoxin

• AlphaFold DB: G4CKR4