Detailed information of TA system TA168979

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 1287035..1287690
• Replicon: chromosome
• Accession: NZ_CP059566
• Organism: Neisseria sicca strain DSM 17713

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: C6M797
• Locus tag: H3L95_RS06235
• Protein ID: WP_003759608.1
• Coordinates: 1287265..1287690 (+)
• Length: 142 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: H3L95_RS06230
• Protein ID: WP_040668749.1
• Coordinates: 1287035..1287265 (+)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H3L95_RS06215	1283662..1285026	+	1365	WP_003759617.1	hypothetical protein	-
H3L95_RS06220	1285184..1285600	+	417	WP_094105976.1	ribbon-helix-helix domain-containing protein	-
H3L95_RS06225	1285612..1286847	+	1236	WP_003759612.1	hypothetical protein	-
H3L95_RS06230	1287035..1287265	+	231	WP_040668749.1	antitoxin	Antitoxin
H3L95_RS06235	1287265..1287690	+	426	WP_003759608.1	type II toxin-antitoxin system VapC family toxin	Toxin
H3L95_RS06240	1287939..1290701	-	2763	WP_003759606.1	TonB-dependent receptor	-
H3L95_RS06245	1291170..1291844	+	675	WP_003759605.1	Fic family protein	-
H3L95_RS06250	1291858..1292484	+	627	WP_003759603.1	recombinase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-123)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 142 a.a.
• Molecular weight: 15309.79 Da
• Isoelectric Point: 5.7469

>T168979 WP_003759608.1 NZ_CP059566:1287265-1287690 [Neisseria sicca]
MILVDTNIISEPLRPKPDSAVIAWLDRQPVETLYLSSITVAELRFGIAILPEGGKKRLLLEKLEETVLPVFSDRILDFDI
EAAVAYAEVRATARAAGFTVAAADGYIAAIARYHHMTVATRDTTPFTAAGLKVINPFLGGK

Nucleotide

• Length: 426 bp

>T168979 NZ_CP076265:62806-63204 [Escherichia coli]
ATGCTGAAGTTTATGCTCGATACCAACATCTGCATTTTTACGATAAAGAACAAACCCGCCAGTGTCAGGGAACGTTTTAA
CCTGAACCAGGGGAGAATGTGCATCAGTTCGGTCACCCTGATGGAGCTGATATATGGTGCAGAAAAAAGCCAGATGCCTG
AACGTAATCTCGCTGTGATCGAGGGATTTGTTTCCCGCATTGACGTTCTGGATTACGACGCTGCTGCTGCCACACACACC
GGCCAGATAAGAGCAGAACTTGCCCGTCAGGGACGCCCTGTCGGGCCATTTGATCAAATGATCGCAGGTCATGCCCGCAG
TCGGGGACTGATTATTGTGACTAATAACACCCGGGAATTTGAACGTGTGGGCGGCCTGAGAATTGAAGACTGGAGTTGA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8481.64 Da
• Isoelectric Point: 8.9952

>AT168979 WP_040668749.1 NZ_CP059566:1287035-1287265 [Neisseria sicca]
MPSITVRNLSEETHRALKARALAAGRSTEAEIRLILDQAARPKQRIRLGSLLSDIGREAGGVDLDIERQEQTEVRF

Nucleotide

• Length: 231 bp

>AT168979 NZ_CP076265:62579-62806 [Escherichia coli]
ATGGAAACCACCGTATTTCTCAGCAACCGCAGCCAGGCGGTCAGACTGCCAAAAGCGGTTGCATTGCCGGAAAACGTAAA
ACGCGTTGAAGTGATTGCTGTCGGACGAACCCGAATCATTACGCCTGCCGGAGAGACATGGGACGAATGGTTCGACGGAA
ACAGTGTCAGCGCTGATTTTATGGATAACAGGGAACAGCCTGGTATGCAGGAAAGGGAGTCATTCTGA

Structures

Toxin

• AlphaFold DB: C6M797