Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PumA-hicB/upstrm_HI1419-HicB |
| Location | 1453167..1454006 | Replicon | chromosome |
| Accession | NZ_CP059565 | ||
| Organism | Neisseria wadsworthii strain DSM 22245 | ||
Toxin (Protein)
| Gene name | PumA | Uniprot ID | G4CPJ0 |
| Locus tag | H3L96_RS06880 | Protein ID | WP_009116142.1 |
| Coordinates | 1453701..1454006 (+) | Length | 102 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | - |
| Locus tag | H3L96_RS06875 | Protein ID | WP_182073123.1 |
| Coordinates | 1453167..1453583 (+) | Length | 139 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| H3L96_RS06850 | 1448227..1448448 | + | 222 | WP_156792969.1 | hypothetical protein | - |
| H3L96_RS06855 | 1448913..1451192 | + | 2280 | WP_156793026.1 | phage tail tape measure protein | - |
| H3L96_RS06860 | 1451195..1451647 | + | 453 | WP_009116138.1 | phage tail protein | - |
| H3L96_RS06865 | 1451647..1452822 | + | 1176 | WP_182073122.1 | late control protein | - |
| H3L96_RS06870 | 1452923..1453108 | + | 186 | WP_009116140.1 | type II toxin-antitoxin system HicA family toxin | - |
| H3L96_RS06875 | 1453167..1453583 | + | 417 | WP_182073123.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| H3L96_RS06880 | 1453701..1454006 | + | 306 | WP_009116142.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| H3L96_RS06885 | 1454003..1454284 | + | 282 | WP_009116143.1 | putative addiction module antidote protein | - |
| H3L96_RS06890 | 1454353..1454706 | - | 354 | WP_182073124.1 | hypothetical protein | - |
| H3L96_RS06895 | 1454703..1455194 | - | 492 | WP_182073125.1 | hypothetical protein | - |
| H3L96_RS06900 | 1455244..1455750 | - | 507 | WP_182073126.1 | WYL domain-containing protein | - |
| H3L96_RS06905 | 1455846..1456499 | - | 654 | WP_182073127.1 | helix-turn-helix domain-containing protein | - |
| H3L96_RS06910 | 1456774..1456977 | + | 204 | WP_182073128.1 | hypothetical protein | - |
| H3L96_RS06915 | 1457083..1457394 | + | 312 | WP_182073129.1 | ogr/Delta-like zinc finger family protein | - |
| H3L96_RS06920 | 1457407..1457937 | + | 531 | WP_182073130.1 | hypothetical protein | - |
| H3L96_RS06925 | 1457930..1458319 | + | 390 | WP_009116151.1 | hypothetical protein | - |
| H3L96_RS06930 | 1458350..1458589 | + | 240 | WP_182073131.1 | hypothetical protein | - |
| H3L96_RS06935 | 1458625..1458771 | + | 147 | WP_182073132.1 | hypothetical protein | - |
| H3L96_RS06940 | 1458752..1458994 | + | 243 | WP_182073133.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1431364..1463399 | 32035 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 102 a.a. Molecular weight: 11510.32 Da Isoelectric Point: 10.1258
>T168977 WP_009116142.1 NZ_CP059565:1453701-1454006 [Neisseria wadsworthii]
MNIIEQTEHFASWLKSLKDYQAKAAILKRIKRMESGLFGDVKSIKNGLFEMRIDVGQGWRVYYFRSGETVYLLIHGGSKS
GQQADIEQALAMKQAIQEGKK
MNIIEQTEHFASWLKSLKDYQAKAAILKRIKRMESGLFGDVKSIKNGLFEMRIDVGQGWRVYYFRSGETVYLLIHGGSKS
GQQADIEQALAMKQAIQEGKK
Download Length: 306 bp
>T168977 NZ_CP076264:4723647-4723997 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA
Antitoxin
Download Length: 139 a.a. Molecular weight: 15324.19 Da Isoelectric Point: 4.4749
>AT168977 WP_182073123.1 NZ_CP059565:1453167-1453583 [Neisseria wadsworthii]
MIYYPVAIFRSDGEAGYGVIIPDLPGCYPVGDTVEEALADAKGAALFHIEGSIEEGLGFETHPKSIEEHRANPDYVEAVL
WAMIEIDETAFTKQTRFNVSWPEYLLEQVDRYAAANHETRSGFLAKAAQSAMRRNAVK
MIYYPVAIFRSDGEAGYGVIIPDLPGCYPVGDTVEEALADAKGAALFHIEGSIEEGLGFETHPKSIEEHRANPDYVEAVL
WAMIEIDETAFTKQTRFNVSWPEYLLEQVDRYAAANHETRSGFLAKAAQSAMRRNAVK
Download Length: 417 bp
>AT168977 NZ_CP076264:4723402-4723653 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAAGCGCAGGTGAGCAACAACCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAAGCGCAGGTGAGCAACAACCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|