Detailed information of TA system TA168976

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1452923..1453583
• Replicon: chromosome
• Accession: NZ_CP059565
• Organism: Neisseria wadsworthii strain DSM 22245

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: G4CPI8
• Locus tag: H3L96_RS06870
• Protein ID: WP_009116140.1
• Coordinates: 1452923..1453108 (+)
• Length: 62 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: H3L96_RS06875
• Protein ID: WP_182073123.1
• Coordinates: 1453167..1453583 (+)
• Length: 139 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H3L96_RS06850	1448227..1448448	+	222	WP_156792969.1	hypothetical protein	-
H3L96_RS06855	1448913..1451192	+	2280	WP_156793026.1	phage tail tape measure protein	-
H3L96_RS06860	1451195..1451647	+	453	WP_009116138.1	phage tail protein	-
H3L96_RS06865	1451647..1452822	+	1176	WP_182073122.1	late control protein	-
H3L96_RS06870	1452923..1453108	+	186	WP_009116140.1	type II toxin-antitoxin system HicA family toxin	Toxin
H3L96_RS06875	1453167..1453583	+	417	WP_182073123.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
H3L96_RS06880	1453701..1454006	+	306	WP_009116142.1	type II toxin-antitoxin system RelE/ParE family toxin	-
H3L96_RS06885	1454003..1454284	+	282	WP_009116143.1	putative addiction module antidote protein	-
H3L96_RS06890	1454353..1454706	-	354	WP_182073124.1	hypothetical protein	-
H3L96_RS06895	1454703..1455194	-	492	WP_182073125.1	hypothetical protein	-
H3L96_RS06900	1455244..1455750	-	507	WP_182073126.1	WYL domain-containing protein	-
H3L96_RS06905	1455846..1456499	-	654	WP_182073127.1	helix-turn-helix domain-containing protein	-
H3L96_RS06910	1456774..1456977	+	204	WP_182073128.1	hypothetical protein	-
H3L96_RS06915	1457083..1457394	+	312	WP_182073129.1	ogr/Delta-like zinc finger family protein	-
H3L96_RS06920	1457407..1457937	+	531	WP_182073130.1	hypothetical protein	-
H3L96_RS06925	1457930..1458319	+	390	WP_009116151.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1431364..1463399	32035

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-128)

Sequences

Toxin

Protein

• Length: 62 a.a.
• Molecular weight: 6945.03 Da
• Isoelectric Point: 10.7837

>T168976 WP_009116140.1 NZ_CP059565:1452923-1453108 [Neisseria wadsworthii]
MKSSELIAIIEADGWKLVRVKGSHHQFKKEGVNHLITISHPEKDVSRHQVADARRKSGLKF

Nucleotide

• Length: 186 bp

>T168976 NZ_CP076264:4620039-4620212 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin

Protein

• Length: 139 a.a.
• Molecular weight: 15324.19 Da
• Isoelectric Point: 4.4749

>AT168976 WP_182073123.1 NZ_CP059565:1453167-1453583 [Neisseria wadsworthii]
MIYYPVAIFRSDGEAGYGVIIPDLPGCYPVGDTVEEALADAKGAALFHIEGSIEEGLGFETHPKSIEEHRANPDYVEAVL
WAMIEIDETAFTKQTRFNVSWPEYLLEQVDRYAAANHETRSGFLAKAAQSAMRRNAVK

Nucleotide

• Length: 417 bp

>AT168976 NZ_CP076264:4619715-4620011 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCTTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAATT
CTTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Structures

Toxin

• AlphaFold DB: G4CPI8