Detailed information of TA system TA168968

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-PumB/upstrm_HI1419-dnstrm_HI1420
• Location: 423951..424553
• Replicon: chromosome
• Accession: NZ_CP059560
• Organism: Aromatoleum petrolei strain ToN1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: ToN1_RS01880
• Protein ID: WP_169208500.1
• Coordinates: 424263..424553 (-)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: PumB
• Uniprot ID: -
• Locus tag: ToN1_RS01875
• Protein ID: WP_169208499.1
• Coordinates: 423951..424253 (-)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ToN1_RS01855 (ToN1_03910)	420014..420187	-	174	WP_169208482.1	hypothetical protein	-
ToN1_RS01860 (ToN1_03920)	420265..421770	-	1506	WP_169208496.1	aldehyde dehydrogenase family protein	-
ToN1_RS01865 (ToN1_03930)	421796..421942	-	147	WP_169208497.1	hypothetical protein	-
ToN1_RS01870 (ToN1_03940)	422092..422994	+	903	WP_169208498.1	LysR family transcriptional regulator	-
ToN1_RS01875 (ToN1_03950)	423951..424253	-	303	WP_169208499.1	putative addiction module antidote protein	Antitoxin
ToN1_RS01880 (ToN1_03960)	424263..424553	-	291	WP_169208500.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
ToN1_RS01885 (ToN1_03970)	425048..426472	-	1425	WP_210147981.1	aldehyde dehydrogenase family protein	-
ToN1_RS01890 (ToN1_03980)	426606..427583	-	978	WP_169208168.1	YCF48-related protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	adeG	371378..807178	435800

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (13-92)

Antitoxin

• Uncharacterized protein HI1420 (7-95)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 10720.38 Da
• Isoelectric Point: 7.8227

>T168968 WP_169208500.1 NZ_CP059560:c424553-424263 [Aromatoleum petrolei]
MKTTLTTEFFDAWFACLRDPQAAARIKMRIGRAELGDFGDCESVGEGVSEMRIHYGPGYRVYFTQRGMEVVILLAGGDKT
TQAKDIKTALKLAREL

Nucleotide

• Length: 291 bp

>T168968 NZ_CP076264:c2237689-2237438 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 10756.42 Da
• Isoelectric Point: 7.3582

>AT168968 WP_169208499.1 NZ_CP059560:c424253-423951 [Aromatoleum petrolei]
MALKLRKWNTAEHLKTEEEMALYLEACLQEAGDDAAFIAKALGDIARAKGMTQLAKDTGLGRESLYKALSGEGNPSFATI
LKVTHALGLQLHAAPRHAPV

Nucleotide

• Length: 303 bp

>AT168968 NZ_CP076264:c2237441-2237187 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA