Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PHD(antitoxin)
Location 1360174..1360874 Replicon chromosome
Accession NZ_CP059557
Organism Saccharopolyspora gloriosae strain MLY014

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag H2Q94_RS05905 Protein ID WP_243792911.1
Coordinates 1360482..1360874 (+) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag H2Q94_RS05900 Protein ID WP_243792908.1
Coordinates 1360174..1360485 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H2Q94_RS05885 1355327..1356484 + 1158 WP_243792904.1 flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase -
H2Q94_RS05890 1356707..1357543 + 837 WP_243792907.1 GNAT family N-acetyltransferase -
H2Q94_RS05895 1358413..1360149 + 1737 WP_243795559.1 penicillin-binding transpeptidase domain-containing protein -
H2Q94_RS05900 1360174..1360485 + 312 WP_243792908.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
H2Q94_RS05905 1360482..1360874 + 393 WP_243792911.1 type II toxin-antitoxin system VapC family toxin Toxin
H2Q94_RS05910 1361007..1361864 + 858 WP_243792914.1 type I methionyl aminopeptidase -
H2Q94_RS05915 1361861..1363684 + 1824 WP_243792915.1 cobyric acid synthase -
H2Q94_RS05920 1363651..1364349 - 699 WP_243792916.1 FadR/GntR family transcriptional regulator -
H2Q94_RS05925 1364453..1365745 + 1293 WP_243792917.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-117)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-51)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14033.07 Da        Isoelectric Point: 4.5822

>T168965 WP_243792911.1 NZ_CP059557:1360482-1360874 [Saccharopolyspora gloriosae]
MIYFDSSALVKLIAPEPESKALSEWVQARLEQPRITSALSQVDVLRTFREFGPAIEDLASIILSKLDQLPVKQDVLDTAA
SLRSQVSPLEAIHLASACKIREGLHAYVSYDKALLAAAEEEGLATASPGA

Download         Length: 393 bp

>T168965 NZ_CP076264:c1775111-1774824 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11295.36 Da        Isoelectric Point: 4.3566

>AT168965 WP_243792908.1 NZ_CP059557:1360174-1360485 [Saccharopolyspora gloriosae]
MERIGVRELRQNASRYLKRVATGESILVTDRGRTVAVLNPPSRAHSLYDELIAAGELIPGDGGDLPEPGEPDAGDLDTWP
PEDEEPGSRTAPPGDDRREQERH

Download         Length: 312 bp

>AT168965 NZ_CP076264:c1775350-1775111 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References