168964

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 6195928..6196721 Replicon chromosome
Accession NZ_CP059556
Organism Saccharopolyspora gregorii strain BM8-3

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag H1226_RS27360 Protein ID WP_258344251.1
Coordinates 6195928..6196260 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID -
Locus tag H1226_RS27365 Protein ID WP_258344253.1
Coordinates 6196263..6196721 (-) Length 153 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1226_RS27340 6191625..6192209 - 585 WP_224960063.1 TetR family transcriptional regulator -
H1226_RS27345 6192206..6192508 - 303 WP_255615369.1 multidrug efflux SMR transporter -
H1226_RS27350 6192618..6193082 - 465 WP_258344245.1 DUF1707 domain-containing protein -
H1226_RS27355 6193522..6195858 + 2337 WP_258344246.1 (Fe-S)-binding protein -
H1226_RS27360 6195928..6196260 - 333 WP_258344251.1 PIN domain-containing protein Toxin
H1226_RS27365 6196263..6196721 - 459 WP_258344253.1 helix-turn-helix domain-containing protein Antitoxin
H1226_RS27370 6196915..6197154 - 240 WP_258344255.1 hypothetical protein -
H1226_RS27375 6197458..6198864 - 1407 WP_258344256.1 sugar porter family MFS transporter -
H1226_RS27380 6199135..6199719 - 585 WP_224960069.1 dCTP deaminase -
H1226_RS27390 6199949..6200272 - 324 WP_258344258.1 TetR family transcriptional regulator C-terminal domain-containing protein -
H1226_RS27395 6200243..6201019 + 777 WP_258344261.1 alpha/beta hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-95)

Antitoxin

Helix-turn-helix domain, group 17

(83-131)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 12547.31 Da        Isoelectric Point: 4.5335

>T168964 WP_258344251.1 NZ_CP059556:c6196260-6195928 [Saccharopolyspora gregorii]
VAFTVVYDADVLYPSTLRDLLIRLAQAGLVQAKWTDQILDETFRNTQRNRPDLDPRNLDRTRELMLRAVRDCLVKGYEPL
IDVLDLPDPDDRHVLGRDGLVESTAALQAM

Download         Length: 333 bp

>T168964 NZ_CP076264:c1693900-1692578 [Escherichia coli]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCCAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CAGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCTAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTAACGTTATTACCCGAAAA
TGAAACCATAACGCGCCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGGCTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCTCTGGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCGCAGGAGAAGACAGCGCTG
CTTAGAATAGGCAATGACTGGTGCATTCCGAAAGGAATAACGCCGACGACGCACATCATTAAATTACCGATTGGCGAAAT
CAGGCAGCCCAATGCGACGCTCGATCTCAGCCAAAGCGTTGATAATGAGTATTACTGTCTGCTGCTGGCGAAAGAACTTG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAATGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATGCTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGTCAGACATTCGGTTTACCTTCATCGGTGAAATA
TGAATCAGATGGAGGCCCAGGCATCGCGCGGATCATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTGAAAGATCGCTATG
ATTTTATGAAATTCCAGGTCTTCCAGTGGTTGATTGGCGCAACGGACGGTCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTCCTTGGCGGTACGGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTTTGGCGACAGCAAAGGTGCTGAGATTCCCGGAAGTGCAGATGCATGAAATCCTAAGTGACTTTGCCAGAATGATTCCG
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAACCAATGTGTT
GAGGTTGCATGGACGGTTAAGCCGAGAATACGGTAGTAAGTGA

Antitoxin


Download         Length: 153 a.a.        Molecular weight: 16666.92 Da        Isoelectric Point: 5.2845

>AT168964 WP_258344253.1 NZ_CP059556:c6196721-6196263 [Saccharopolyspora gregorii]
MNSLALDPIQPDGADAAVADEALQRIKGYLGRHQDQRRIPLVVEDDGCETLVVPRGAVELLARVLAHMAAGTGVSVVPSH
AELTTQQAAEMLNVSRPFLVGLLEAGEIDHRKVGTHRRVRAESVLAYLREDDKRRREAADELTRLTQEMGLD

Download         Length: 459 bp

>AT168964 NZ_CP076264:c1694166-1693900 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTAGCGAATGCAATGAAACTGGTTCGCCAGCAAAATGGCTGGAC
GCAGAGCGAGCTGGCGAAAAAAATTGGCATTAAGCAGGCGACAATTTCCAATTTCGAAAACAACCCTGACAATACCACGC
TCACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACACTATGCGACACGAAAAATGCCTCGCCAGAATCA
ACAGAACAGCAAGATCTGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References