Detailed information of TA system TA168962

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PHD(antitoxin)
• Location: 1408087..1408733
• Replicon: chromosome
• Accession: NZ_CP059556
• Organism: Saccharopolyspora gregorii strain BM8-3

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: H1226_RS06140
• Protein ID: WP_224956832.1
• Coordinates: 1408341..1408733 (+)
• Length: 131 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: H1226_RS06135
• Protein ID: WP_224956833.1
• Coordinates: 1408087..1408344 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H1226_RS06120	1403743..1404900	+	1158	WP_258347791.1	flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase	-
H1226_RS06125	1405173..1406009	+	837	WP_258347793.1	GNAT family N-acetyltransferase	-
H1226_RS06130	1406247..1408010	+	1764	WP_258349353.1	penicillin-binding transpeptidase domain-containing protein	-
H1226_RS06135	1408087..1408344	+	258	WP_224956833.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
H1226_RS06140	1408341..1408733	+	393	WP_224956832.1	PIN domain-containing protein	Toxin
H1226_RS06145	1408798..1409655	+	858	WP_224956831.1	type I methionyl aminopeptidase	-
H1226_RS06150	1409652..1411184	+	1533	WP_225044739.1	cobyric acid synthase	-
H1226_RS06155	1411204..1411473	+	270	WP_225044738.1	type II toxin-antitoxin system prevent-host-death family antitoxin	-
H1226_RS06160	1411440..1412138	-	699	WP_224966995.1	FadR/GntR family transcriptional regulator	-
H1226_RS06165	1412242..1413528	+	1287	WP_224956827.1	MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-112)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-52)

Sequences

Toxin

Protein

• Length: 131 a.a.
• Molecular weight: 13879.94 Da
• Isoelectric Point: 4.9000

>T168962 WP_224956832.1 NZ_CP059556:1408341-1408733 [Saccharopolyspora gregorii]
MIYFDSSALVKLIAPEPESVALSEWVRARLEQPRITSAISQVDVLRTFREQGPAIEDLATIVLSKLDRLPVKQDVLDGAA
ALRSRVSPLEAIHLASACKLREGLHAYVSYDGALLAAAAEEGLATASPGA

Nucleotide

• Length: 393 bp

>T168962 NZ_CP076264:c1313203-1313096 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9421.49 Da
• Isoelectric Point: 4.7037

>AT168962 WP_224956833.1 NZ_CP059556:1408087-1408344 [Saccharopolyspora gregorii]
MERIGVRELRQNASRYLRRVATGESILITDRGRTVAVLNPPSRERSLYDELIAAGELIPGDGGELPEPLDADGPLGDDRG
ERERH

Nucleotide

• Length: 258 bp

>AT168962 NZ_CP076264:1313250-1313316 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT