Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/-
Location 449612..450265 Replicon chromosome
Accession NZ_CP059547
Organism Acinetobacter baumannii strain 10_3

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag H2784_RS02175 Protein ID WP_000607070.1
Coordinates 449876..450265 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V5V966
Locus tag H2784_RS02170 Protein ID WP_001288210.1
Coordinates 449612..449869 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H2784_RS02150 (H2784_02150) 445126..446133 + 1008 WP_000198631.1 DNA-directed RNA polymerase subunit alpha -
H2784_RS02155 (H2784_02155) 446152..446529 + 378 WP_001216380.1 50S ribosomal protein L17 -
H2784_RS02160 (H2784_02160) 446712..448202 + 1491 WP_016686239.1 NAD(P)/FAD-dependent oxidoreductase -
H2784_RS02165 (H2784_02165) 448252..449424 - 1173 WP_001190546.1 acyl-CoA dehydrogenase family protein -
H2784_RS02170 (H2784_02170) 449612..449869 + 258 WP_001288210.1 succinate dehydrogenase assembly factor 2 Antitoxin
H2784_RS02175 (H2784_02175) 449876..450265 + 390 WP_000607070.1 hypothetical protein Toxin
H2784_RS02180 (H2784_02180) 451035..452120 + 1086 WP_000049106.1 hypothetical protein -
H2784_RS02185 (H2784_02185) 452198..452764 + 567 WP_000651536.1 rhombosortase -
H2784_RS02190 (H2784_02190) 452952..455147 + 2196 WP_223069863.1 TRAP transporter large permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 15708.02 Da        Isoelectric Point: 10.3599

>T168960 WP_000607070.1 NZ_CP059547:449876-450265 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAILFYQLMPLLWWLVVISLLFISFIFFLKRPQLAKIAYLDKKLWSLAYHSQNTI
SRVKILKIIDYQIFIVIYFEDHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Download         Length: 390 bp

>T168960 NZ_CP076264:c1312132-1312025 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10318.77 Da        Isoelectric Point: 4.6150

>AT168960 WP_001288210.1 NZ_CP059547:449612-449869 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Download         Length: 258 bp

>AT168960 NZ_CP076264:1312180-1312246 [Escherichia coli]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BQM7

References