Detailed information of TA system TA168959

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 449603..450256
• Replicon: chromosome
• Accession: NZ_CP059546
• Organism: Acinetobacter baumannii strain 10_4

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: H2785_RS02170
• Protein ID: WP_000607070.1
• Coordinates: 449867..450256 (+)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: V5V966
• Locus tag: H2785_RS02165
• Protein ID: WP_001288210.1
• Coordinates: 449603..449860 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H2785_RS02145 (H2785_02145)	445117..446124	+	1008	WP_000198631.1	DNA-directed RNA polymerase subunit alpha	-
H2785_RS02150 (H2785_02150)	446143..446520	+	378	WP_001216380.1	50S ribosomal protein L17	-
H2785_RS02155 (H2785_02155)	446703..448193	+	1491	WP_016686239.1	NAD(P)/FAD-dependent oxidoreductase	-
H2785_RS02160 (H2785_02160)	448243..449415	-	1173	WP_001190546.1	acyl-CoA dehydrogenase family protein	-
H2785_RS02165 (H2785_02165)	449603..449860	+	258	WP_001288210.1	succinate dehydrogenase assembly factor 2	Antitoxin
H2785_RS02170 (H2785_02170)	449867..450256	+	390	WP_000607070.1	hypothetical protein	Toxin
H2785_RS02175 (H2785_02175)	451026..452111	+	1086	WP_000049106.1	hypothetical protein	-
H2785_RS02180 (H2785_02180)	452189..452755	+	567	WP_000651536.1	rhombosortase	-
H2785_RS02185 (H2785_02185)	452943..455138	+	2196	WP_223069863.1	TRAP transporter large permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (10-82)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 15708.02 Da
• Isoelectric Point: 10.3599

>T168959 WP_000607070.1 NZ_CP059546:449867-450256 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAILFYQLMPLLWWLVVISLLFISFIFFLKRPQLAKIAYLDKKLWSLAYHSQNTI
SRVKILKIIDYQIFIVIYFEDHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Nucleotide

• Length: 390 bp

>T168959 NZ_CP076264:c551395-551177 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10318.77 Da
• Isoelectric Point: 4.6150

>AT168959 WP_001288210.1 NZ_CP059546:449603-449860 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Nucleotide

• Length: 258 bp

>AT168959 NZ_CP076264:c551795-551421 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Structures

Antitoxin

• AlphaFold DB: A0A7U4BQM7