Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/-
Location 460876..461529 Replicon chromosome
Accession NZ_CP059542
Organism Acinetobacter baumannii strain E-011922

Toxin (Protein)


Gene name cptA Uniprot ID A0A009PMF4
Locus tag H2786_RS02260 Protein ID WP_032058676.1
Coordinates 461140..461529 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V5V966
Locus tag H2786_RS02255 Protein ID WP_001288210.1
Coordinates 460876..461133 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H2786_RS02235 (H2786_02235) 456392..457399 + 1008 WP_000198631.1 DNA-directed RNA polymerase subunit alpha -
H2786_RS02240 (H2786_02240) 457418..457795 + 378 WP_001216380.1 50S ribosomal protein L17 -
H2786_RS02245 (H2786_02245) 457977..459467 + 1491 WP_000415133.1 NAD(P)/FAD-dependent oxidoreductase -
H2786_RS02250 (H2786_02250) 459516..460688 - 1173 WP_032058675.1 acyl-CoA dehydrogenase family protein -
H2786_RS02255 (H2786_02255) 460876..461133 + 258 WP_001288210.1 succinate dehydrogenase assembly factor 2 Antitoxin
H2786_RS02260 (H2786_02260) 461140..461529 + 390 WP_032058676.1 membrane protein Toxin
H2786_RS02265 (H2786_02265) 462299..463384 + 1086 WP_000049106.1 hypothetical protein -
H2786_RS02270 (H2786_02270) 463462..464028 + 567 WP_000651536.1 rhombosortase -
H2786_RS02275 (H2786_02275) 464216..466411 + 2196 WP_001158905.1 TRAP transporter large permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 15575.86 Da        Isoelectric Point: 10.4637

>T168958 WP_032058676.1 NZ_CP059542:461140-461529 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFIIGLSLAVLFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYHSQNTI
SRVKILKIIDYQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLH

Download         Length: 390 bp

>T168958 NZ_CP076264:c517411-516869 [Escherichia coli]
ATGGTCGACAAGCATGAAGAGATTACTCTGCCCATAGTCCTCTCCTGTAATTATCAGTCTGATATTACTTATCCTGGGCA
AAAACAGTTTGATTGCGGTAACCCTGTTATCGATAAATTTGTACGCGCATCGCTAAAGAAAAGTGTGCGTAATAGCGACT
GTGCGGCTAAAGCACTTATTGACAGACAAAGTGGTGAACTGATCGGCATCTGTACTTTTACGGCATATTCGCTGGAAAAA
CAACGCGTTTCTGGCGTCCTTCAGGGTTCACAACCTTCAGAAATTGGTGTTGTCAGATTAGTCATGTTGGGGGTAGCACG
GAAGTATCAAAAGCGGGGCTTTGGTCAGGACCTACTATGTGATTTTTTTGAACATGTAAAAATAATTCACCAGGCATTAC
CAATTAAAGGGGTTTATCTTGATGCTGACCCTGCCGCCATTAATTTTTATGCTCGTCTCGGCTTTGTTCAGCTTTCAGCG
ACACCAAATGCTTTTGGTGCTGTACCTATGTTTTTGGCGATTCAGCATATTCTCGCGGCTTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10318.77 Da        Isoelectric Point: 4.6150

>AT168958 WP_001288210.1 NZ_CP059542:460876-461133 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Download         Length: 258 bp

>AT168958 NZ_CP076264:c517706-517395 [Escherichia coli]
ATGCCTGGAAAAACAGCCACTCTACCCGATGTCGATAAAACGCTGAAAAATGCGCGGGTCGAACTCAAAACCAGTCCCGA
CGCCAAAAACAAACTTCGTGAAGCTGCGCAAGCCGTTGGGGTAGATTTAAGCGCTTTTATTTTGAGCGCTGCTATGGAAC
GCGCCGAAAGTGTGCTTGATAACCAACGTCGCCGTGAGCTTTCGAATCAAAGCTGGGAACTGATGAACCAACTCATCGCT
GAACCTGCTCAACCGACGCTCGCCCTCAAGGCGTTAATGAAAAGGAAAAACAGCGATGGTCGACAAGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A009PMF4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BQM7

References