Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 529105..529744 Replicon chromosome
Accession NZ_CP059540
Organism Planococcus maritimus strain XJ11

Toxin (Protein)


Gene name pemK Uniprot ID A0A1C7EC77
Locus tag H1Q58_RS02775 Protein ID WP_058381776.1
Coordinates 529394..529744 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A1C7DXF0
Locus tag H1Q58_RS02770 Protein ID WP_068460417.1
Coordinates 529105..529389 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1Q58_RS02745 524798..525277 + 480 WP_068460409.1 PH domain-containing protein -
H1Q58_RS02750 525270..526832 + 1563 WP_182093399.1 PH domain-containing protein -
H1Q58_RS02755 526859..527473 - 615 WP_068488988.1 rhomboid family intramembrane serine protease -
H1Q58_RS02760 527542..527895 + 354 WP_182092656.1 holo-ACP synthase -
H1Q58_RS02765 527912..529060 + 1149 WP_182092657.1 alanine racemase -
H1Q58_RS02770 529105..529389 + 285 WP_068460417.1 transcriptional regulator Antitoxin
H1Q58_RS02775 529394..529744 + 351 WP_058381776.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
H1Q58_RS02780 529922..530752 + 831 WP_182093400.1 STAS domain-containing protein -
H1Q58_RS02785 530749..531111 + 363 WP_068460422.1 STAS domain-containing protein -
H1Q58_RS02790 531114..531515 + 402 WP_068460424.1 anti-sigma regulatory factor -
H1Q58_RS02795 531528..532529 + 1002 WP_182092658.1 PP2C family protein-serine/threonine phosphatase -
H1Q58_RS02800 532625..532957 + 333 WP_182092659.1 anti-sigma factor antagonist -
H1Q58_RS02805 532960..533430 + 471 WP_068460431.1 anti-sigma B factor RsbW -
H1Q58_RS02810 533408..534190 + 783 WP_182092660.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12850.94 Da        Isoelectric Point: 5.8817

>T168957 WP_058381776.1 NZ_CP059540:529394-529744 [Planococcus maritimus]
MIVKRGDVFFAELSPVVGSEQGGTRPVLVIQNDIGNRFSPTVIIAAITAQIQKAKLPTHVEINAKKYGFERDSVILLEQL
RTIDKSRLTDKITQLDDALMEKVDEALEISVGLVKF

Download         Length: 351 bp

>T168957 NZ_CP076264:c281438-281160 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATTTTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATGCTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10705.07 Da        Isoelectric Point: 5.5819

>AT168957 WP_068460417.1 NZ_CP059540:529105-529389 [Planococcus maritimus]
VYEKSKTKEVVVKLPKQFMSELTAHSGERIEENGEFIYVSTQRVTKNVYDSYHIREAMIKGYVEMSQINLSIACECSHAE
YEAEHTTVQLVSGG

Download         Length: 285 bp

>AT168957 NZ_CP076264:c281701-281441 [Escherichia coli]
ATGGCTGCTAACGCATTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1C7EC77

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7DXF0

References