Detailed information of TA system TA168947

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): spoIISABC/SpoIISA-SpoIISB
• Location: 1670268..1671187
• Replicon: chromosome
• Accession: NZ_CP059494
• Organism: Bacillus haynesii strain P19

Toxin (Protein)

• Gene name: spoIISA
• Uniprot ID: -
• Locus tag: H2R00_RS08220
• Protein ID: WP_154994986.1
• Coordinates: 1670268..1671014 (+)
• Length: 249 a.a.

Antitoxin (Protein)

• Gene name: spoIISB
• Uniprot ID: A0A6C1W1Q1
• Locus tag: H2R00_RS08225
• Protein ID: WP_043925301.1
• Coordinates: 1671014..1671187 (+)
• Length: 58 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H2R00_RS08200	1665659..1666303	-	645	WP_154994990.1	YesL family protein	-
H2R00_RS08205	1666440..1668197	-	1758	WP_154994988.1	gamma-glutamyltransferase	-
H2R00_RS08210	1668530..1669147	+	618	WP_003180884.1	DUF47 domain-containing protein	-
H2R00_RS08215	1669160..1670158	+	999	WP_075753239.1	inorganic phosphate transporter	-
H2R00_RS08220	1670268..1671014	+	747	WP_154994986.1	type II toxin-antitoxin system SpoIISA family toxin	Toxin
H2R00_RS08225	1671014..1671187	+	174	WP_043925301.1	type II toxin-antitoxin system SpoIISB family antitoxin	Antitoxin
H2R00_RS08230	1671477..1672749	-	1273	Protein_1639	MFS transporter	-
H2R00_RS08235	1672800..1673813	-	1014	WP_182070816.1	zinc-binding alcohol dehydrogenase family protein	-
H2R00_RS08240	1673839..1674687	-	849	WP_182070817.1	SDR family oxidoreductase	-
H2R00_RS08245	1674663..1675760	-	1098	WP_182070818.1	mannonate dehydratase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SpoIISA, type II toxin-antitoxin system (3-238)

Antitoxin

• Antitoxin SpoIISB (1-57)

Sequences

Toxin

Protein

• Length: 249 a.a.
• Molecular weight: 29398.84 Da
• Isoelectric Point: 4.5417

>T168947 WP_154994986.1 NZ_CP059494:1670268-1671014 [Bacillus haynesii]
MLLFYQFLVWLIVLALSLYVAAVWCFEKKLTEKTVAIRKTWYLLYVIGAVIYWTHDPQSIFTNPLHYLIVAVFFTLTDAF
IFLNAYFKKLGSSELATDTRMLLEENNDLLHTYQNRLKTFQYLLKNEPIHIYYGNIEAYAEGIEKLIKRFAEKMNISAAL
CEYNSEESKDHLLEHMENRFDVQEKLERKDVYYEENGKMVLIPFSIHDFDYVMKLTSEDLVTEFDYLLFTSLTSIYDLLL
PNEEEGDD

Nucleotide

• Length: 747 bp

>T168947 NZ_CP076262:c2812172-2811774 [Escherichia coli]
ATGCTGAAATTCATGCTGGATACCAATATCTGTATTTTCACTATTAAGAATAAACCAGTACATGTCAGAGAGCGGTTTAA
CCTGAATTCTGGCCGGATGTGTATAAGTTCTGTAACATTGATGGAGCTTATCTATGGGGCAGAAAAAAGTCAGATGCCAG
AACGCAATTTGGCGGTGATTGAAGGTTTCGTATCTCGTTTGGAAGTGCTTGATTATGATAGTGCTGCTGCGACGCATACC
GGGCAAATCAGGGCCGAGCTTGCCCGGCAGGGAAGGCCTGTTGGACCTTTTGACCAGATGATAGCGGGACATGCTCGCAG
TCGCGGTTTGATTGTGGTTACCAACAATACCCGAGAGTTTGAGCGAGTGGCGGGAATCAGACTAGAAGATTGGAGCTAA

Antitoxin

Protein

• Length: 58 a.a.
• Molecular weight: 6917.03 Da
• Isoelectric Point: 10.8356

>AT168947 WP_043925301.1 NZ_CP059494:1671014-1671187 [Bacillus haynesii]
MEPAFQQDQESVKKRLAFKMFKKQSKTNIAKYEVSPHTERIFRQNERLIGEYKRKKA

Nucleotide

• Length: 174 bp

>AT168947 NZ_CP076262:c2812399-2812172 [Escherichia coli]
ATGGAAACTACTGTATTTTTAAGTAATCGCAGTCAGGCCGTCAGATTACCGAAAGCGGTCGCTCTGCCAGAGGATGTTAA
GAAAGTAGAAATTATTGCGATTGGTCGTACAAGAATCATCACTCCCGCCGGTGAGTCCTGGGACAGTTGGTTTGATGGCG
AAAATGTGAGTGCGGATTTTATGGATATCCGTGATCAACCCGCAATGCAGGAAAGGGAATCATTCTGA

Structures

Antitoxin

• AlphaFold DB: A0A6C1W1Q1