Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 1122241..1122761 Replicon chromosome
Accession NZ_CP059492
Organism Arcanobacterium sp. JY-X040

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag H2O17_RS04885 Protein ID WP_182050665.1
Coordinates 1122471..1122761 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag H2O17_RS04880 Protein ID WP_182050663.1
Coordinates 1122241..1122474 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H2O17_RS04850 1118354..1118923 + 570 WP_182050651.1 16S rRNA (guanine(966)-N(2))-methyltransferase RsmD -
H2O17_RS04855 1118920..1119408 + 489 WP_182050653.1 pantetheine-phosphate adenylyltransferase -
H2O17_RS04860 1119405..1119995 + 591 WP_182050655.1 hypothetical protein -
H2O17_RS04865 1119986..1120552 + 567 WP_182050657.1 DUF177 domain-containing protein -
H2O17_RS04870 1120549..1121352 + 804 WP_182050659.1 ribonuclease III -
H2O17_RS04875 1121352..1122179 + 828 WP_182050661.1 bifunctional DNA-formamidopyrimidine glycosylase/DNA-(apurinic or apyrimidinic site) lyase -
H2O17_RS04880 1122241..1122474 + 234 WP_182050663.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
H2O17_RS04885 1122471..1122761 + 291 WP_182050665.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H2O17_RS04890 1123070..1123687 + 618 WP_182050943.1 response regulator transcription factor -
H2O17_RS04895 1123759..1124463 - 705 WP_182050667.1 TetR/AcrR family transcriptional regulator -
H2O17_RS04900 1124694..1126961 + 2268 WP_182050669.1 glycoside hydrolase family 3 C-terminal domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-92)

Antitoxin

Antitoxin ParD

(1-73)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11522.03 Da        Isoelectric Point: 6.2327

>T168946 WP_182050665.1 NZ_CP059492:1122471-1122761 [Arcanobacterium sp. JY-X040]
VSAFRLTPAAQRDLSEIWDFTQKRWDVVQAEEYIAEIRDAIERVAKEPNRGRRCDEIRDGYRRYVVGSHLVFFVEYEDAI
DVIRILHQRMDPTRHM

Download         Length: 291 bp

>T168946 NZ_CP076262:c2307108-2306857 [Escherichia coli]
ATGCGTACAATTAGTTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8359.38 Da        Isoelectric Point: 5.0351

>AT168946 WP_182050663.1 NZ_CP059492:1122241-1122474 [Arcanobacterium sp. JY-X040]
MATNTSISLDDHFAAFLAREVATGRYRSASEVVRAGLRLLEDQETQIAALRSALIAGEESGRAEPFNFDAFIVAKKS

Download         Length: 234 bp

>AT168946 NZ_CP076262:c2306860-2306606 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAACCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References