Detailed information of TA system TA168945

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pezAT/zeta-ParD
• Location: 4556104..4557053
• Replicon: chromosome
• Accession: NZ_CP059491
• Organism: Gordonia jinghuaiqii strain zg-686

Toxin (Protein)

• Gene name: pezT
• Uniprot ID: -
• Locus tag: H1R19_RS20325
• Protein ID: WP_188331396.1
• Coordinates: 4556104..4556673 (-)
• Length: 190 a.a.

Antitoxin (Protein)

• Gene name: pezA
• Uniprot ID: -
• Locus tag: H1R19_RS20330
• Protein ID: WP_188331442.1
• Coordinates: 4556670..4557053 (-)
• Length: 128 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H1R19_RS20300 (H1R19_20295)	4551634..4552311	-	678	WP_244970776.1	HAD-IB family phosphatase	-
H1R19_RS20305 (H1R19_20300)	4552366..4553460	-	1095	WP_188331393.1	LLM class flavin-dependent oxidoreductase	-
H1R19_RS20310 (H1R19_20305)	4553691..4554758	-	1068	WP_219849987.1	phosphotriesterase	-
H1R19_RS20315 (H1R19_20310)	4554817..4555635	+	819	WP_219851808.1	aldo/keto reductase	-
H1R19_RS20320 (H1R19_20315)	4555704..4556048	+	345	WP_188331395.1	cupin domain-containing protein	-
H1R19_RS20325 (H1R19_20320)	4556104..4556673	-	570	WP_188331396.1	zeta toxin family protein	Toxin
H1R19_RS20330 (H1R19_20325)	4556670..4557053	-	384	WP_188331442.1	hypothetical protein	Antitoxin
H1R19_RS20335 (H1R19_20330)	4557200..4557748	-	549	WP_219849989.1	peptide-methionine (S)-S-oxide reductase MsrA	-
H1R19_RS20340 (H1R19_20335)	4557745..4558239	-	495	WP_188331398.1	peptide-methionine (R)-S-oxide reductase MsrB	-
H1R19_RS20345 (H1R19_20340)	4558356..4558592	+	237	WP_188331399.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (2-142)

Antitoxin

• ParD-like antitoxin of type II bacterial toxin-antitoxin system (7-63)

Sequences

Toxin

Protein

• Length: 190 a.a.
• Molecular weight: 20843.72 Da
• Isoelectric Point: 8.1632

>T168945 WP_188331396.1 NZ_CP059491:c4556673-4556104 [Gordonia jinghuaiqii]
VSPRLDLVVGCNGAGKSTLVERHLQPLLHTPFVNADLIAGQKWPDAAQAHSYDAARLAAATRDALIGNGTSFIAETVFSH
PSKLELLDRAHAAGYRVVLHVLLIPEELAVHRVRLRVDSGGHAVPEHKIRERYQRLWPLIREAITRSDQATVYANESPTT
RIVARFVDGMPAGSPDWPRWSPTALTEGW

Nucleotide

• Length: 570 bp

>T168945 NZ_CP076262:c2306860-2306606 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAACCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin

Protein

• Length: 128 a.a.
• Molecular weight: 13720.10 Da
• Isoelectric Point: 4.9861

>AT168945 WP_188331442.1 NZ_CP059491:c4557053-4556670 [Gordonia jinghuaiqii]
MSTGTDKVTRLSAALVSDAAREGAREQRSARQQLEHWARLGRSVSQRTTASRRRVEAALAGGLPGESLTPEETVVYDAEI
DAQLEARLADDDHVVRRASEGFSSVVVDDAGRLVEYRPDGTSVVLGQ

Nucleotide

• Length: 384 bp

>AT168945 NZ_CP076262:c2307108-2306857 [Escherichia coli]
ATGCGTACAATTAGTTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA