Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/COG3657-dnstrm_HI1420
Location 335955..336484 Replicon plasmid unnamed
Accession NZ_CP059490
Organism Ralstonia solanacearum strain YQ

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag H2F19_RS18900 Protein ID WP_016722340.1
Coordinates 335955..336182 (+) Length 76 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag H2F19_RS18905 Protein ID WP_016722339.1
Coordinates 336179..336484 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H2F19_RS18880 332192..332791 - 600 WP_016722344.1 GNAT family N-acetyltransferase -
H2F19_RS18885 332924..333475 + 552 WP_016722343.1 helix-turn-helix transcriptional regulator -
H2F19_RS18890 333653..334474 + 822 WP_011003398.1 GntR family transcriptional regulator -
H2F19_RS18895 334601..335800 + 1200 WP_016726513.1 MFS transporter -
H2F19_RS18900 335955..336182 + 228 WP_016722340.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H2F19_RS18905 336179..336484 + 306 WP_016722339.1 putative addiction module antidote protein Antitoxin
H2F19_RS18910 336697..338010 + 1314 WP_038938025.1 metabolite/H+ symporter -
H2F19_RS18915 338115..338783 - 669 WP_038938024.1 hypothetical protein -
H2F19_RS18920 338950..339167 - 218 Protein_238 transposase -
H2F19_RS18925 339472..339756 + 285 WP_011003391.1 hypothetical protein -
H2F19_RS18930 339887..340168 + 282 WP_016722336.1 hypothetical protein -
H2F19_RS18935 340499..340984 - 486 WP_016726511.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - cyaB / motA / cheW / cheB / cheY / adeG / htpB / acrB / fliI / fliG / fliM / flgG / flgC 1..2039736 2039736
- flank IS/Tn - - 341219..342184 965


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(2-67)

Antitoxin

Cro/C1-type helix-turn-helix domain

(52-96)


Sequences

Toxin        


Download         Length: 76 a.a.        Molecular weight: 8566.85 Da        Isoelectric Point: 7.2789

>T168944 WP_016722340.1 NZ_CP059490:335955-336182 [Ralstonia solanacearum]
VRIDRLQMGHPGNMKAVRDGIRELRIDHGPGDRLYFVRHGVVLIVLLCGGDKSTQETDIRRAIDLSRRLDVDDME

Download         Length: 228 bp

>T168944 NZ_CP076262:c2102632-2102529 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 10967.57 Da        Isoelectric Point: 7.2780

>AT168944 WP_016722339.1 NZ_CP059490:336179-336484 [Ralstonia solanacearum]
MTMAQRTIKTRPWDSAEHLRTEADIAAYLDACLEEAGDDPAFITHALGVVARSRGMTQLARETGMTREGLYKALSEGGNP
SFATVLKVIRALGIRLHAVPT

Download         Length: 306 bp

>AT168944 NZ_CP076262:2102491-2102762 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References