Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-UPF0150
Location 2424264..2424701 Replicon chromosome
Accession NZ_CP059488
Organism Acidithiobacillus ferrivorans strain XJFY6S-08

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag H2515_RS12105 Protein ID WP_198660244.1
Coordinates 2424264..2424488 (-) Length 75 a.a.

Antitoxin (Protein)


Gene name hicA Uniprot ID G0JN17
Locus tag H2515_RS12110 Protein ID WP_014028381.1
Coordinates 2424492..2424701 (-) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H2515_RS12085 2420465..2421940 + 1476 WP_198660242.1 YdiU family protein -
H2515_RS12090 2422009..2422617 - 609 WP_198660243.1 uracil-DNA glycosylase family protein -
H2515_RS12095 2423001..2423531 - 531 WP_035193711.1 GNAT family N-acetyltransferase -
H2515_RS12100 2423528..2423809 - 282 WP_198661469.1 DUF1778 domain-containing protein -
H2515_RS12105 2424264..2424488 - 225 WP_198660244.1 type II toxin-antitoxin system HicA family toxin Toxin
H2515_RS12110 2424492..2424701 - 210 WP_014028381.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
H2515_RS12115 2424862..2426202 - 1341 WP_198661470.1 group II intron reverse transcriptase/maturase -
H2515_RS12120 2426693..2427046 - 354 WP_198660245.1 hypothetical protein -
H2515_RS12125 2427043..2427483 - 441 WP_198660246.1 hypothetical protein -
H2515_RS12130 2427809..2428448 + 640 Protein_2379 phage integrase N-terminal SAM-like domain-containing protein -
H2515_RS12135 2428470..2428850 - 381 WP_065412485.1 hypothetical protein -
H2515_RS12140 2428915..2429436 - 522 WP_065412484.1 inorganic diphosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(10-65)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 75 a.a.        Molecular weight: 8371.91 Da        Isoelectric Point: 10.9142

>T168939 WP_198660244.1 NZ_CP059488:c2424488-2424264 [Acidithiobacillus ferrivorans]
MGNIPVLKPNEVIAILIKLGFMEVRQRGSHKQFRDTAGRCTTVPFHQGRDISPILLRQIAKDIGLALDELLKHR

Download         Length: 225 bp

>T168939 NZ_CP076262:c1354217-1354110 [Escherichia coli]
ATGACGCTCGCGAAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 7455.47 Da        Isoelectric Point: 4.0818

>AT168939 WP_014028381.1 NZ_CP059488:c2424701-2424492 [Acidithiobacillus ferrivorans]
MKVYSAVIERCPQTGLFVGFVPGFPGAHSQGETLDEVNHNLHDVIAMLLEDGEPMLESEFVGVQNVAIA

Download         Length: 210 bp

>AT168939 NZ_CP076262:1354270-1354331 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1E7XQE4

References