Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2107517..2108319 Replicon chromosome
Accession NZ_CP059488
Organism Acidithiobacillus ferrivorans strain XJFY6S-08

Toxin (Protein)


Gene name TacT3 Uniprot ID -
Locus tag H2515_RS10510 Protein ID WP_198660054.1
Coordinates 2107792..2108319 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID -
Locus tag H2515_RS10505 Protein ID WP_198660053.1
Coordinates 2107517..2107795 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H2515_RS10470 2102593..2103960 - 1368 WP_198660049.1 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase -
H2515_RS10475 2103974..2104564 - 591 WP_014028536.1 hypothetical protein -
H2515_RS10480 2104545..2105327 - 783 WP_198660050.1 thiazole synthase -
H2515_RS10485 2105372..2105572 - 201 WP_014028534.1 sulfur carrier protein ThiS -
H2515_RS10490 2105670..2106524 - 855 WP_198660051.1 S-formylglutathione hydrolase -
H2515_RS10495 2106675..2107097 - 423 WP_198660052.1 type II toxin-antitoxin system VapC family toxin -
H2515_RS10500 2107097..2107339 - 243 WP_065413372.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
H2515_RS10505 2107517..2107795 + 279 WP_198660053.1 DUF1778 domain-containing protein Antitoxin
H2515_RS10510 2107792..2108319 + 528 WP_198660054.1 GNAT family N-acetyltransferase Toxin
H2515_RS10515 2108928..2109344 + 417 WP_198660055.1 DNA cytosine methyltransferase -
H2515_RS10520 2109344..2110183 + 840 WP_083091501.1 DUF3883 domain-containing protein -
H2515_RS10525 2110192..2110353 + 162 WP_198660056.1 AIPR family protein -
H2515_RS10530 2110707..2111606 + 900 WP_198660057.1 patatin-like phospholipase family protein -
H2515_RS10535 2111625..2112683 - 1059 WP_198660058.1 tRNA 2-thiouridine(34) synthase MnmA -
H2515_RS10540 2112697..2112891 - 195 WP_035194150.1 Fe-S cluster assembly protein IscX -
H2515_RS10545 2112891..2113229 - 339 WP_035194148.1 ISC system 2Fe-2S type ferredoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(11-87)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 18922.93 Da        Isoelectric Point: 9.9535

>T168938 WP_198660054.1 NZ_CP059488:2107792-2108319 [Acidithiobacillus ferrivorans]
MNLPDWHEAPISKAHDRAAFDCGEAELNAFLRRHARQNHEKGGAKTFVATPIGDDKRVLGFYSLSPASIDYARTPALVKK
GLARHDVPVFRLGRLAVDKTVQRHGLGGQLLLVAGRRCILAATEIGGIALLIDAKNERVAAWYKAYGALPLLDAPQSLLL
PLSTVEAALKEAGKL

Download         Length: 528 bp

>T168938 NZ_CP076262:c1353682-1353575 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10305.97 Da        Isoelectric Point: 8.9086

>AT168938 WP_198660053.1 NZ_CP059488:2107517-2107795 [Acidithiobacillus ferrivorans]
MPRTIVENNNRLALRVRPDDKATLMRAVALEHTDMTDFILRHALDAARKVIEQAEHLALSERDSLRVLDALENPPVPNAK
LLAAARHLPKGL

Download         Length: 279 bp

>AT168938 NZ_CP076262:1353730-1353796 [Escherichia coli]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTAAACCTCTCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References