Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 1838439..1838969 Replicon chromosome
Accession NZ_CP059488
Organism Acidithiobacillus ferrivorans strain XJFY6S-08

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag H2515_RS09150 Protein ID WP_198659920.1
Coordinates 1838769..1838969 (+) Length 67 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag H2515_RS09145 Protein ID WP_198659919.1
Coordinates 1838439..1838708 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H2515_RS09120 1836153..1836437 + 285 WP_198659915.1 TIR domain-containing protein -
H2515_RS09125 1836434..1836898 + 465 WP_012535904.1 helix-turn-helix domain-containing protein -
H2515_RS09130 1836899..1837471 + 573 WP_198659916.1 PIN domain-containing protein -
H2515_RS09135 1837595..1837753 + 159 WP_198659917.1 transposase -
H2515_RS09140 1837826..1838266 - 441 WP_198659918.1 1-acyl-sn-glycerol-3-phosphate acyltransferase -
H2515_RS09145 1838439..1838708 + 270 WP_198659919.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
H2515_RS09150 1838769..1838969 + 201 WP_198659920.1 type II toxin-antitoxin system YafQ family toxin Toxin
H2515_RS09155 1839493..1840590 + 1098 WP_198659921.1 HNH endonuclease -
H2515_RS09160 1840494..1841738 - 1245 WP_198659922.1 DNA (cytosine-5-)-methyltransferase -
H2515_RS09165 1842240..1842689 - 450 WP_198659923.1 single-stranded DNA-binding protein -
H2515_RS09170 1842751..1843641 - 891 WP_198659924.1 DNA adenine methylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1807777..1850225 42448


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-65)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(8-82)


Sequences

Toxin        


Download         Length: 67 a.a.        Molecular weight: 7602.73 Da        Isoelectric Point: 7.2418

>T168936 WP_198659920.1 NZ_CP059488:1838769-1838969 [Acidithiobacillus ferrivorans]
MKRKPVLVALVTDQPLDACYRDHDLSGDWAGYRECHVKPDLLLIYRKSDFDTLRLARLGSHSELFG

Download         Length: 201 bp

>T168936 NZ_CP076262:c288243-287965 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATTTTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATGCTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9705.07 Da        Isoelectric Point: 5.6976

>AT168936 WP_198659919.1 NZ_CP059488:1838439-1838708 [Acidithiobacillus ferrivorans]
MSTTTDTYVRARIDTNTKERAASALEAMGLSVSDAIRLLMLRIADEHRLPFDVKVPNATTKKALAELEAGKGKKFASVDD
LMADLHADD

Download         Length: 270 bp

>AT168936 NZ_CP076262:c288506-288246 [Escherichia coli]
ATGGCTGCTAACGCATTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References