Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-DUF971
Location 1783242..1783837 Replicon chromosome
Accession NZ_CP059488
Organism Acidithiobacillus ferrivorans strain XJFY6S-08

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag H2515_RS08860 Protein ID WP_198661447.1
Coordinates 1783541..1783837 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A7T4WBH3
Locus tag H2515_RS08855 Protein ID WP_012535948.1
Coordinates 1783242..1783538 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H2515_RS08840 1778715..1779704 - 990 WP_198659869.1 ABC transporter substrate-binding protein -
H2515_RS08845 1780231..1782285 + 2055 WP_198661446.1 DNA topoisomerase 3 -
H2515_RS08850 1782282..1782530 + 249 WP_054608944.1 hypothetical protein -
H2515_RS08855 1783242..1783538 - 297 WP_012535948.1 putative addiction module antidote protein Antitoxin
H2515_RS08860 1783541..1783837 - 297 WP_198661447.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H2515_RS08865 1784017..1784610 + 594 WP_198659870.1 hypothetical protein -
H2515_RS08870 1784607..1785971 + 1365 WP_198659871.1 conjugal transfer protein TraB -
H2515_RS08875 1785971..1786186 + 216 WP_198659872.1 hypothetical protein -
H2515_RS08880 1786158..1786763 + 606 WP_198659873.1 S26 family signal peptidase -
H2515_RS08885 1786844..1787239 + 396 WP_198659874.1 hypothetical protein -
H2515_RS08890 1787242..1788012 + 771 WP_198659875.1 ParA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-96)

Antitoxin

Uncharacterized protein HI1420

(11-92)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11252.00 Da        Isoelectric Point: 10.2647

>T168934 WP_198661447.1 NZ_CP059488:c1783837-1783541 [Acidithiobacillus ferrivorans]
MTELKQTETFRRWWTKLKDERARGIVAGRLDRLAYGLIGDAEPVGEGISELRIHYGPGYRVYFQQRGSMIIVLLCGGNKN
TQAKDIKVAKRLAAEWRE

Download         Length: 297 bp

>T168934 NZ_CP076261:c45554-45402 [Escherichia coli]
ATGCCACAGCGAACATTTTTAATGATGTTGATCGTCGTCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGGGCTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 10231.66 Da        Isoelectric Point: 5.8085

>AT168934 WP_012535948.1 NZ_CP059488:c1783538-1783242 [Acidithiobacillus ferrivorans]
MSEKLSTFDPAEGLTSDAAIAAFMADAFESADAGYIAHALGVVARAKGMAQIAGETGLSREQLYRSFSERGNPTLKTTLA
VMKVLGIELTAKPGPQGR

Download         Length: 297 bp

>AT168934 NZ_CP076261:45604-45666 [Escherichia coli]
TCGAAGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7T4WBH3

References