Detailed information of TA system TA168931

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 1521802..1522463
• Replicon: chromosome
• Accession: NZ_CP059488
• Organism: Acidithiobacillus ferrivorans strain XJFY6S-08

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: H2515_RS07540
• Protein ID: WP_198661339.1
• Coordinates: 1521802..1522230 (-)
• Length: 143 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A060UU47
• Locus tag: H2515_RS07545
• Protein ID: WP_035192793.1
• Coordinates: 1522230..1522463 (-)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H2515_RS07520	1519332..1519538	+	207	WP_198661431.1	CDGSH iron-sulfur domain-containing protein	-
H2515_RS07525	1519572..1520216	+	645	WP_198661038.1	YceI family protein	-
H2515_RS07530	1520277..1521155	+	879	WP_198661337.1	hypothetical protein	-
H2515_RS07535	1521187..1521657	+	471	WP_198661338.1	VOC family protein	-
H2515_RS07540	1521802..1522230	-	429	WP_198661339.1	PIN domain-containing protein	Toxin
H2515_RS07545	1522230..1522463	-	234	WP_035192793.1	hypothetical protein	Antitoxin
H2515_RS07550	1522732..1523256	+	525	WP_198661340.1	methylated-DNA--[protein]-cysteine S-methyltransferase	-
H2515_RS07555	1523253..1524722	-	1470	WP_198661341.1	helix-turn-helix domain-containing protein	-
H2515_RS07560	1524885..1525325	+	441	WP_014029068.1	DUF2384 domain-containing protein	-
H2515_RS07565	1525289..1525795	+	507	WP_198661342.1	RES family NAD+ phosphorylase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain toxin (1-126)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 143 a.a.
• Molecular weight: 15559.88 Da
• Isoelectric Point: 6.2016

>T168931 WP_198661339.1 NZ_CP059488:c1522230-1521802 [Acidithiobacillus ferrivorans]
MTFLLDVNVLIALIDPMHVQHDMAHEWFAAHGQPAWATCPLTENGVLRIVGHPRYPNSPGTPAAVAPLIQGLRASPGHVF
WPDDISLLDVDHIDASRLFTSGQITDSYLLALACAHEGQLVTFDHRLVINAVRNGLQCINKI

Nucleotide

• Length: 429 bp

>T168931 NZ_CP076259:4704312-4705259 [Escherichia coli]
ATGGATGATTTAACCACTCTTTTTTCTGAAGTGGCTGACGCGCTTGGTATTGAGTCTGTCGCAATTGTGGAAAAAGATCA
CTATATCGTTGAGCTTTTGCAATTGCTTAAACCTCTGGTGTTCGATACTCATCAATTGGTGTTTGCCGGAGGAACCGCTC
TGGCAAAATCAGGTGTCGCACTTAATCGCATGTCGGAAGATGTGGATATCAAACTGGTGCCTAAGGATGCATTTCAGGCA
CTTTCCCGCACTCAGCGAAAAAATACCCGTAAAGAAATTGTTCAGGCAGTTTCCAGTGCAATAGCTTCATCGGGTGTGTT
CAATTTTGATGATGATTACCCAAAAGTGACGCGGGATGAATATCGTTATAATGACATACCTGTTCGTTATCCACAGCGAG
TAGTGCAGGCACCTTGTTTGCGTCCTTTTATCCGGCTGGAACTGATGGAAGCGAAGTTACTGGAGCCTTCTGAATTACGG
GATATTCATTCACTGGTAACAGGGATCACGGGAAAAGCGGCTATTGTTTCAGCGTTTCCATGCGCAACTATCATTAGCAC
ACAGGCAGAAAAGCTGGTGGCGATGTTACGTCGTACTGCGGCAGTTGTGCGAGATGTTGAGCGATTTGATGATGCATCGC
TGGTACGTCATATCTACGATACAAACTGTATTGTTGAGACGAGTCATGTTGATATGAGTCTGCTCGTTGATTTTGTTCAA
CAAACTATTGAGCAGGACATTCAGCGTTACGGCAACCAGTACCCGCAGTTTTGCGCGTCTCCAGTTGATGAGCTAAAAAT
GGGACTGGATGAGTTGGCGAACAATCCTCTCTACCAGATGCGCTATCAGCAGTTTGTTTCGCCAATGGTGTATGGAGAGC
GAAAGATCACATGGGATGAGGCTTACTCCAGGTTTAGGAGCTTAGCGCTAGCCATCCTGAATGCTTGA

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8182.40 Da
• Isoelectric Point: 7.2027

>AT168931 WP_035192793.1 NZ_CP059488:c1522463-1522230 [Acidithiobacillus ferrivorans]
MRTTLAIDDDVLAAAKGLADRQHKPVGAVVSALLRQALQPQNTSGGHSRNGIPLLPVRPDALPATLEIVNQLRDELP

Nucleotide

• Length: 234 bp

>AT168931 NZ_CP076259:4703924-4704319 [Escherichia coli]
ATGACGATAAAAGCACGCATTCAGTCACGACTGAAACGTTCTAAACGTTACGTATTCACTCGTGACGACTTTAAAGATAT
TGCAGGCTACGATCAGGTTGGTCGGGTATTGCGCGATCTTGTCAGGGAAGGGCAACTGTTGAAGGTTGGTTATGGCGTGT
ATACCAAAGCACGGCGGAACGGTATTACAGGCAAGGTAATGCCAGCGGCTCCCGGAGGCTCTTCAGCGGTGATTGTCGAA
ACGCTGGAACGCCTGAAAGTACGCTATCGTTTTGCTGGCGCAACGCAGGCATACAATAGCGGTACTTCTACGCAGATCCC
AGCTTCACCCGAGATAAAAACCCCCCGGCGTTTTAAACGCGTATTATCTGTAGGGAACAGCAGATTAAATGGATGA

Structures

Antitoxin

• AlphaFold DB: A0A060UU47