Detailed information of TA system TA168930

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapC-vagC/VapC-VagC
• Location: 1048833..1049473
• Replicon: chromosome
• Accession: NZ_CP059488
• Organism: Acidithiobacillus ferrivorans strain XJFY6S-08

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: H2515_RS05350
• Protein ID: WP_065413981.1
• Coordinates: 1048833..1049237 (-)
• Length: 135 a.a.

Antitoxin (Protein)

• Gene name: vagC
• Uniprot ID: -
• Locus tag: H2515_RS05355
• Protein ID: WP_035191736.1
• Coordinates: 1049237..1049473 (-)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H2515_RS05315	1044903..1045343	-	441	WP_198661413.1	VOC family protein	-
H2515_RS05320	1045646..1046395	-	750	WP_198661102.1	PilZ domain-containing protein	-
H2515_RS05325	1046451..1047200	-	750	WP_035191739.1	PilZ domain-containing protein	-
H2515_RS05330	1047280..1047744	-	465	WP_198661103.1	LexA family transcriptional regulator	-
H2515_RS05335	1047854..1048231	-	378	WP_198661414.1	type II toxin-antitoxin system VapC family toxin	-
H2515_RS05340	1048237..1048482	-	246	WP_198661104.1	type II toxin-antitoxin system prevent-host-death family antitoxin	-
H2515_RS05345	1048563..1048799	-	237	Protein_1046	integration host factor subunit alpha	-
H2515_RS05350	1048833..1049237	-	405	WP_065413981.1	type II toxin-antitoxin system VapC family toxin	Toxin
H2515_RS05355	1049237..1049473	-	237	WP_035191736.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
H2515_RS05360	1049673..1050185	-	513	WP_085537847.1	pyridoxamine 5'-phosphate oxidase family protein	-
H2515_RS05365	1050648..1051397	-	750	WP_198661105.1	PilZ domain-containing protein	-
H2515_RS05370	1051755..1051973	+	219	WP_035190049.1	hypothetical protein	-
H2515_RS05375	1052035..1052325	-	291	WP_035190050.1	integration host factor subunit alpha	-
H2515_RS05380	1052499..1053608	-	1110	WP_198661106.1	ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1043415..1044677	1262

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-119)

Antitoxin

• SpoVT-AbrB domain (7-46)

Sequences

Toxin

Protein

• Length: 135 a.a.
• Molecular weight: 14904.16 Da
• Isoelectric Point: 4.6436

>T168930 WP_065413981.1 NZ_CP059488:c1049237-1048833 [Acidithiobacillus ferrivorans]
MARYMLDTNMCIYLMKNQPEEVAKRFARCYVGDVVMSSITYAELTYGVAAANDPEQERINLASLVDDIQVAPFDIAAGVS
YGPIRLATRDTRTNALDKLIAAHAISLNVIIVTNNTKDFIKYPGAILENWLLET

Nucleotide

• Length: 405 bp

>T168930 NZ_CP076259:4653558-4653908 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 9051.22 Da
• Isoelectric Point: 5.8432

>AT168930 WP_035191736.1 NZ_CP059488:c1049473-1049237 [Acidithiobacillus ferrivorans]
MHTTRIFKNGNSQAVRIPADIAYERTDMDLEIERDGDEIRIRPARRSLSMVLTKFARFAPDFMAEGRGDQQQVERDPL

Nucleotide

• Length: 237 bp

>AT168930 NZ_CP076259:4653313-4653564 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAAGCGCAGGTGAGCAACAACCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA