Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 314081..314661 Replicon chromosome
Accession NZ_CP059488
Organism Acidithiobacillus ferrivorans strain XJFY6S-08

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag H2515_RS01560 Protein ID WP_198660772.1
Coordinates 314081..314446 (-) Length 122 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag H2515_RS01565 Protein ID WP_198660773.1
Coordinates 314458..314661 (-) Length 68 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H2515_RS01530 310091..310252 + 162 WP_198660766.1 hypothetical protein -
H2515_RS01535 310294..311658 - 1365 WP_198660767.1 HNH endonuclease -
H2515_RS01540 312203..313111 - 909 WP_198660768.1 hypothetical protein -
H2515_RS01545 313108..313500 - 393 WP_198660769.1 clan AA aspartic protease -
H2515_RS01550 313596..313823 - 228 WP_198660770.1 TraY domain-containing protein -
H2515_RS01555 313883..314059 - 177 WP_198660771.1 hypothetical protein -
H2515_RS01560 314081..314446 - 366 WP_198660772.1 type II toxin-antitoxin system VapC family toxin Toxin
H2515_RS01565 314458..314661 - 204 WP_198660773.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
H2515_RS01570 314746..317802 - 3057 WP_198660774.1 conjugal transfer protein TraN -
H2515_RS01575 317805..319052 - 1248 WP_198660775.1 TraU family protein -
H2515_RS01580 319053..319310 - 258 WP_198660776.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 219401..329300 109899


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13552.68 Da        Isoelectric Point: 6.3222

>T168926 WP_198660772.1 NZ_CP059488:c314446-314081 [Acidithiobacillus ferrivorans]
VDTSVWVDHFRHRNDALVELLERDLVMAHPLVLGEIACGTPPNRDKTLSDLDRLQSTQQATVRETMAFIGRERLFGLGCG
LIDILLLASTMITPGTELWTLDKRLCALAERFGVKHGSFLH

Download         Length: 366 bp

>T168926 NZ_CP076259:c3765310-3764783 [Escherichia coli]
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCGTT
AAATCTCTTTCTGACGACACATCTCGTTCGTCAACATCGCAACAAAATTCTGCGAGCGTATATCCTTTGTCGCAACACTC
CAGAACGTCAGGTGCTGGGATATTACACATTATGCGGCAGTTGTTTTGAACGAGCCGCATTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTTACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGGGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAAAGTCGTCTGGTCAGCCTCTTTAGCGGTAGGTATTCACGGTCTTTTTGTCG
AGGCGCTGAATAAAAAAGCCCATACGTTTTATCAATCGCTGGGCTTTATCCCGTTGGTCGGAGAAAACGAAAATGCGTTA
TTTTTCCCAACCAAATCCATCGAACTGCTTTTCACACAGAGCGATTAA

Antitoxin


Download         Length: 68 a.a.        Molecular weight: 7641.76 Da        Isoelectric Point: 5.0492

>AT168926 WP_198660773.1 NZ_CP059488:c314661-314458 [Acidithiobacillus ferrivorans]
MRTTVTIDDVLYERALEVADPDMDKADLFREAIKTFVRVQSAKRLAALGGTVPQMQEIPRRHELAEQ

Download         Length: 204 bp

>AT168926 NZ_CP076259:c3765583-3765317 [Escherichia coli]
ATGTCTGCTGTTAAAAAGCAGCGTATCGATCTGCGTTTAACTGACGATGACAAAAGTATGATTGAGGAAGCGGCAGCGAT
ATCTAATCAGTCCGTCAGCCAATTTATGTTGAACAGCGCTTCGCAGCGGGCTGCGGAAGTGATTGAACAGCATCGGCGGG
TGATCCTCAATGAGGAATCCTGGACGCGGGTGATGGATGCGCTGAGTAATCCACCGTCACCTGGTGAAAAGCTAAAACGT
GCGGCAAAACGTCTTCAGGGAATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References