Detailed information of TA system TA168924

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yoeB-relB/YoeB-YefM
• Location: 51570..52072
• Replicon: chromosome
• Accession: NZ_CP059488
• Organism: Acidithiobacillus ferrivorans strain XJFY6S-08

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: A0A060UM37
• Locus tag: H2515_RS00190
• Protein ID: WP_035191770.1
• Coordinates: 51818..52072 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A060ULQ1
• Locus tag: H2515_RS00185
• Protein ID: WP_035191769.1
• Coordinates: 51570..51821 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H2515_RS00160	46667..47026	-	360	WP_014027549.1	dihydroneopterin aldolase	-
H2515_RS00165	47099..47695	+	597	WP_071182474.1	glycerol-3-phosphate 1-O-acyltransferase PlsY	-
H2515_RS00170	47724..48737	-	1014	WP_198660623.1	tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex transferase subunit TsaD	-
H2515_RS00175	48730..49569	-	840	WP_198660624.1	ferritin-like domain-containing protein	-
H2515_RS00180	49687..51198	-	1512	WP_198660625.1	PQQ-binding-like beta-propeller repeat protein	-
H2515_RS00185	51570..51821	+	252	WP_035191769.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
H2515_RS00190	51818..52072	+	255	WP_035191770.1	Txe/YoeB family addiction module toxin	Toxin
H2515_RS00195	52467..52712	+	246	WP_198661373.1	Arc family DNA-binding protein	-
H2515_RS00200	53346..53645	-	300	WP_198660626.1	hypothetical protein	-
H2515_RS00205	53645..53845	-	201	WP_198660627.1	addiction module protein	-
H2515_RS00210	54009..54302	-	294	WP_198660628.1	type II toxin-antitoxin system RelE/ParE family toxin	-
H2515_RS00215	54299..54523	-	225	WP_198660629.1	addiction module protein	-
H2515_RS00220	54698..55109	-	412	Protein_43	hypothetical protein	-
H2515_RS00225	55597..56640	-	1044	WP_198660630.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10207.69 Da
• Isoelectric Point: 8.5126

>T168924 WP_035191770.1 NZ_CP059488:51818-52072 [Acidithiobacillus ferrivorans]
VRLIFSDDAWEDYLYWQKQDKRMVERINKLIHETQREPFAGVGKPEALKHALSGFWSRRITDEHRMVYRIEGDALMIAQL
RFHY

Nucleotide

• Length: 255 bp

>T168924 NZ_CP076259:c3190961-3190554 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGTGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9118.51 Da
• Isoelectric Point: 6.9767

>AT168924 WP_035191769.1 NZ_CP059488:51570-51821 [Acidithiobacillus ferrivorans]
MDAITYTTVRANLASAMDRVCDDHEPLIITRNGEQSVVMLSLEDYKALEETAYLLRTPANAKRLLAAVAQLNAGKGVERK
LAK

Nucleotide

• Length: 252 bp

>AT168924 NZ_CP076259:c3191208-3190942 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Toxin

• AlphaFold DB: A0A060UM37

Antitoxin

• AlphaFold DB: A0A060ULQ1