Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 3601804..3602482 Replicon chromosome
Accession NZ_CP059479
Organism Acinetobacter baumannii strain 17-84

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag H2Q98_RS17930 Protein ID WP_057077657.1
Coordinates 3602300..3602482 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag H2Q98_RS17925 Protein ID WP_057077658.1
Coordinates 3601804..3602208 (-) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H2Q98_RS17920 3600969..3601658 - 690 WP_057077659.1 hypothetical protein -
H2Q98_RS17925 3601804..3602208 - 405 WP_057077658.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
H2Q98_RS17930 3602300..3602482 - 183 WP_057077657.1 type II toxin-antitoxin system HicA family toxin Toxin
H2Q98_RS17935 3602814..3603347 - 534 WP_057077656.1 hypothetical protein -
H2Q98_RS17940 3603394..3604323 - 930 WP_057077655.1 hypothetical protein -
H2Q98_RS17945 3604432..3604644 - 213 WP_057077654.1 hypothetical protein -
H2Q98_RS17950 3604651..3604854 - 204 WP_057077653.1 hypothetical protein -
H2Q98_RS17955 3604856..3605254 - 399 WP_057077652.1 hypothetical protein -
H2Q98_RS17960 3605256..3605624 - 369 WP_057077651.1 hypothetical protein -
H2Q98_RS17965 3605590..3606000 - 411 WP_086225809.1 hypothetical protein -
H2Q98_RS17970 3606012..3606182 - 171 WP_164528213.1 hypothetical protein -
H2Q98_RS17975 3606185..3606451 - 267 WP_086225808.1 hypothetical protein -
H2Q98_RS17980 3606451..3606819 - 369 WP_086225807.1 glutamate 5-kinase -
H2Q98_RS17985 3606819..3607196 - 378 WP_057090125.1 hypothetical protein -
H2Q98_RS17990 3607200..3607481 - 282 WP_057090138.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3562021..3633822 71801


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6682.84 Da        Isoelectric Point: 10.5523

>T168903 WP_057077657.1 NZ_CP059479:c3602482-3602300 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVTGSHHHFKHPTKKGLVTIPHPKKDLPSGTVKSILKQAGLN

Download         Length: 183 bp

>T168903 NZ_CP076257:c1287333-1287040 [Xanthomonas translucens pv. graminis]
ATGACCGAAAACCTGACCACCTACGATCCTGCCGAGGATCTGAACTCCGACCAGGCGATTGCCGATTTCATGGCGGGCGC
CTTTGCGACCAACGACACCGGCTTCATCGCCCATGCCCTCGGCATCGTCGCCCGTGCCAAGGGCATGACCCAGATCGCAC
GACAAACCGGCCTGTCCCGGGAGCAGCTCTACCGCTCCTTCAGCGAGGACGGAAATCCGACGCTGCGCACCACCCTGGCC
GTCATGAAGGCGCTCGGGATCGAACTGACGGCCAAAGCCGCCGTCACGCATTGA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14720.74 Da        Isoelectric Point: 4.3819

>AT168903 WP_057077658.1 NZ_CP059479:c3602208-3601804 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENIKEAISGHLEILAEDGEEIPEASELIKFIDDADYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDDNVGKDKRFKTRSAFLAAGAEKLLHA

Download         Length: 405 bp

>AT168903 NZ_CP076257:c1287632-1287336 [Xanthomonas translucens pv. graminis]
GTGATCGAACTCAAGCAGACCGAGACGTTCCGCAAGTGGCGCACGAAGCTGAAGGACGAGCGCGCTCGCACTGCGATTGC
CTTGCGCTTGACCCGACTTGCCTATGGCCATGCCGGCGATACGGAAGCTGTCGGGCAAGGCATCAGCGAGCTGCGTATCC
ACCATGGCCCCGGATATCGGGTGTATTTCCAGCGGCGCGGCGACACGATCATCGTCTTGCTCTGCGGTGGCGACAAAAGC
TCGCAGGCAAAGGACATCAAGACAGCCAAACGGCTTGCCGACGAATGGAGCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References