Detailed information of TA system TA168898

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 17573..18122
• Replicon: plasmid p17-84_OXA
• Accession: NZ_CP059478
• Organism: Acinetobacter baumannii strain 17-84

Toxin (Protein)

• Gene name: relE
• Uniprot ID: N9KJ78
• Locus tag: H2Q98_RS00105
• Protein ID: WP_000176412.1
• Coordinates: 17832..18122 (+)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: N9KCM7
• Locus tag: H2Q98_RS00100
• Protein ID: WP_005140357.1
• Coordinates: 17573..17848 (+)
• Length: 92 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H2Q98_RS00070	12906..14066	-	1161	WP_000179382.1	MobA/MobL family protein	-
H2Q98_RS00075	14373..15149	+	777	WP_000191151.1	hypothetical protein	-
H2Q98_RS00080	15374..16573	+	1200	WP_002072939.1	hypothetical protein	-
H2Q98_RS00085	16646..16888	-	243	WP_001015364.1	hypothetical protein	-
H2Q98_RS00090	17037..17261	+	225	WP_002072934.1	hypothetical protein	-
H2Q98_RS00095	17365..17568	+	204	WP_182923962.1	hypothetical protein	-
H2Q98_RS00100	17573..17848	+	276	WP_005140357.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
H2Q98_RS00105	17832..18122	+	291	WP_000176412.1	type II toxin-antitoxin system YafQ family toxin	Toxin
H2Q98_RS00110	18170..18316	-	147	WP_000192351.1	hypothetical protein	-
H2Q98_RS00115	18313..18834	-	522	WP_000999915.1	hypothetical protein	-
H2Q98_RS00120	19398..19928	-	531	WP_000172759.1	hypothetical protein	-
H2Q98_RS00125	20077..20379	+	303	WP_000286964.1	type II toxin-antitoxin system RelE/ParE family toxin	-
H2Q98_RS00130	20380..20661	+	282	WP_000985609.1	putative addiction module antidote protein	-
H2Q98_RS00135	20741..21160	-	420	WP_001180106.1	SMI1/KNR4 family protein	-
H2Q98_RS00140	21300..21620	+	321	WP_000897307.1	type II toxin-antitoxin system RelE/ParE family toxin	-
H2Q98_RS00145	21613..21885	+	273	WP_000369781.1	helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	blaOXA-58 / msr(E) / mph(E) / aph(6)-Id / aph(3'')-Ib / blaPER-1 / aph(3')-VIb / sul2 / aac(3)-IId	-	1..108715	108715
	-	flank	IS/Tn	msr(E) / mph(E)	-	22378..25806	3428

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (4-96)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (9-75)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11187.12 Da
• Isoelectric Point: 6.9783

>T168898 WP_000176412.1 NZ_CP059478:17832-18122 [Acinetobacter baumannii]
MTLTIRYKKQFKKDFKRVSSNPKLKKGLLILKDLIDEHLVKTGTVPDEYLPHPLIGEWKPHMECHILPDLLLIWDVDEDN
NELILARIGSHSELFG

Nucleotide

• Length: 291 bp

>T168898 NZ_CP076255:256912-257046 [Xanthomonas translucens pv. graminis]
ATGAAGCGTACGTTTGCGTGGATGCTGCTGGCGATGTTTTCGGTGGGCCTGCTGTCGGGCTGCAACACGGTTGCCGGTGC
CGGCAAGGACGTGAAGAGCGCCGGCGAGAAGGTCGAAGACGCCGCCAAGAACTGA

Antitoxin

Protein

• Length: 92 a.a.
• Molecular weight: 10290.65 Da
• Isoelectric Point: 4.6702

>AT168898 WP_005140357.1 NZ_CP059478:17573-17848 [Acinetobacter baumannii]
MNTLAKKDEYVRARVPNELKVQAERILKEVGLNTTDAIRLLLTQVVNRGGFPLELRTPNRTTIEAMNSVAEPKKFSSAQE
LFTDLEDDTDD

Nucleotide

• Length: 276 bp

>AT168898 NZ_CP076255:256660-256812 [Xanthomonas translucens pv. graminis]
ATGAAGCGACTGTTCACCTTGACGATGCTGACCCTGTTCTGTGCAGGCATGCTGACTGGCTGCAACACCATGGCCGGTGC
TGGCAAGGATATGCAGAAGGCCGGCGATAAGGTGGAAACCAAGGCCGACGACTGCAAAGACGGCAAGTGCTGA

Structures

Toxin

• AlphaFold DB: N9KJ78

Antitoxin

• AlphaFold DB: N9KCM7