Detailed information of TA system TA168896

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 2301636..2302453
• Replicon: chromosome
• Accession: NZ_CP059477
• Organism: Morganella morganii strain S164-3

Toxin (Protein)

• Gene name: TacT2
• Uniprot ID: -
• Locus tag: H1R77_RS11200
• Protein ID: WP_015422406.1
• Coordinates: 2301947..2302453 (+)
• Length: 169 a.a.

Antitoxin (Protein)

• Gene name: TacA2
• Uniprot ID: J7TDK6
• Locus tag: H1R77_RS11195
• Protein ID: WP_004236533.1
• Coordinates: 2301636..2301944 (+)
• Length: 103 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H1R77_RS11170	2296943..2297149	-	207	WP_004236540.1	4-oxalocrotonate tautomerase family protein	-
H1R77_RS11175	2297257..2298249	-	993	WP_087825439.1	inner membrane protein YhjD	-
H1R77_RS11180	2298661..2299050	-	390	WP_004236536.1	DUF1090 domain-containing protein	-
H1R77_RS11185	2299240..2300082	+	843	WP_036417394.1	23S rRNA (adenine(2030)-N(6))-methyltransferase RlmJ	-
H1R77_RS11190	2300152..2301504	+	1353	WP_046024838.1	glutathione-disulfide reductase	-
H1R77_RS11195	2301636..2301944	+	309	WP_004236533.1	DUF1778 domain-containing protein	Antitoxin
H1R77_RS11200	2301947..2302453	+	507	WP_015422406.1	GNAT family N-acetyltransferase	Toxin
H1R77_RS11205	2302567..2302707	-	141	WP_004236531.1	hypothetical protein	-
H1R77_RS11210	2302704..2303225	-	522	WP_015422407.1	isopentenyl-diphosphate Delta-isomerase	-
H1R77_RS11215	2303353..2303655	-	303	WP_004240743.1	HdeA/HdeB family chaperone	-
H1R77_RS11220	2303870..2304388	-	519	WP_223302449.1	molybdopterin-guanine dinucleotide biosynthesis protein MobB	-
H1R77_RS11225	2304395..2304967	-	573	Protein_2188	molybdenum cofactor guanylyltransferase MobA	-
H1R77_RS11230	2305188..2305457	+	270	WP_004240741.1	YihD family protein	-
H1R77_RS11235	2305457..2306452	+	996	WP_004236526.1	serine/threonine protein kinase	-
H1R77_RS11240	2306471..2307094	+	624	WP_004236525.1	thiol:disulfide interchange protein DsbA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (44-143)

Antitoxin

• Vibrio phage ICP1, Orf50 (21-94)

Sequences

Toxin

Protein

• Length: 169 a.a.
• Molecular weight: 18565.43 Da
• Isoelectric Point: 9.9508

>T168896 WP_015422406.1 NZ_CP059477:2301947-2302453 [Morganella morganii]
MNLTAPEPLQQHHDFTVFQSGEESLNHWLKTRALQNQQSGASRTFVVCHHNRIMAYYALSTGVITCSQAAGRFRRNMPPE
IPVILPGRLAVDESVKGRGIGRGLIKDAALRVLQAAGIVGIRGIVVRALSDNARRFYEHTGFMPSPADPMLLMITLRDLQ
LATGIYSE

Nucleotide

• Length: 507 bp

>T168896 NZ_CP076254:3449790-3450083 [Xanthomonas translucens pv. graminis]
ATGACCGAAAACCTGACCACCTACGATCCTGCCGAGGATCTGAACTCCGACCAGGCGATTGCCGATTTCATGGCGGGCGC
CTTTGCGACCAACGACACCGGCTTCATCGCCCATGCCCTCGGCATCGTCGCCCGTGCCAAGGGCATGACCCAGATCGCAC
GACAAACCGGCCTGTCCCGGGAGCAGCTCTACCGCTCCTTCAGCGAGGACGGAAATCCGACGCTGCGCACCACCCTGGCC
GTCATGAAGGCGCTCGGGATCGAACTGACGGCCAAAGCCGCCGTCACGCATTGA

Antitoxin

Protein

• Length: 103 a.a.
• Molecular weight: 11499.15 Da
• Isoelectric Point: 8.6397

>AT168896 WP_004236533.1 NZ_CP059477:2301636-2301944 [Morganella morganii]
MTKHTDEQHPVSGVNITRSTLNLRIKPEDKILIDRAAHAAGKNRTEFVLEAARRAAEETLADLRVIDVSTDVYQQFITRL
DMAPQSGEALKKTMLTKAPWEK

Nucleotide

• Length: 309 bp

>AT168896 NZ_CP076254:3449491-3449787 [Xanthomonas translucens pv. graminis]
GTGATCGAACTCAAGCAGACCGAGACGTTCCGCAAGTGGCGCACGAAGCTGAAGGACGAGCGCGCTCGCACTGCGATTGC
CTTGCGCTTGACCCGACTTGCCTATGGCCATGCCGGCGATACGGAAGCTGTCGGGCAAGGCATCAGCGAGCTGCGTATCC
ACCATGGCCCCGGATATCGGGTGTATTTCCAGCGGCGCGGCGACACGATCATCGTCTTGCTCTGCGGTGGCGACAAAAGC
TCGCAGGCAAAGGACATCAAGACAGCCAAACGGCTTGCCGACGAATGGAGCGAATGA

Structures

Antitoxin

• AlphaFold DB: J7TDK6