Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1197127..1197753 Replicon chromosome
Accession NZ_CP059477
Organism Morganella morganii strain S164-3

Toxin (Protein)


Gene name Hha Uniprot ID A0A0A2RCL2
Locus tag H1R77_RS06005 Protein ID WP_024474604.1
Coordinates 1197550..1197753 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J7U1S9
Locus tag H1R77_RS06000 Protein ID WP_004236473.1
Coordinates 1197127..1197486 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1R77_RS05990 1192177..1193373 + 1197 WP_015422955.1 efflux RND transporter periplasmic adaptor subunit -
H1R77_RS05995 1193388..1196564 + 3177 WP_015422956.1 efflux RND transporter permease subunit -
H1R77_RS06000 1197127..1197486 + 360 WP_004236473.1 Hha toxicity modulator TomB Antitoxin
H1R77_RS06005 1197550..1197753 + 204 WP_024474604.1 HHA domain-containing protein Toxin
H1R77_RS06015 1198638..1199501 + 864 WP_032097922.1 acyl-CoA thioesterase II -
H1R77_RS06020 1199561..1200850 - 1290 WP_064483483.1 ammonium transporter AmtB -
H1R77_RS06025 1200870..1201208 - 339 WP_004236467.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-113)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8073.39 Da        Isoelectric Point: 6.9770

>T168895 WP_024474604.1 NZ_CP059477:1197550-1197753 [Morganella morganii]
MTKLDYLMRLRKCTSIETLERVIEKNKYELTDDELEVFYSAADHRLAELTMNKLYDKIPASVWKFVR

Download         Length: 204 bp

>T168895 NZ_CP076254:3449491-3449787 [Xanthomonas translucens pv. graminis]
GTGATCGAACTCAAGCAGACCGAGACGTTCCGCAAGTGGCGCACGAAGCTGAAGGACGAGCGCGCTCGCACTGCGATTGC
CTTGCGCTTGACCCGACTTGCCTATGGCCATGCCGGCGATACGGAAGCTGTCGGGCAAGGCATCAGCGAGCTGCGTATCC
ACCATGGCCCCGGATATCGGGTGTATTTCCAGCGGCGCGGCGACACGATCATCGTCTTGCTCTGCGGTGGCGACAAAAGC
TCGCAGGCAAAGGACATCAAGACAGCCAAACGGCTTGCCGACGAATGGAGCGAATGA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13826.54 Da        Isoelectric Point: 4.2870

>AT168895 WP_004236473.1 NZ_CP059477:1197127-1197486 [Morganella morganii]
MDEYSPRNYDIAVLKYLCDELCREGTQTLIRSNNYWVNDLASDSNLKLNELLGYIADVAWSFKIKHTQNKDLISFVDEYI
DETYALFGQMEVSFNDVEEWKKMASLVSSMLTSEGHLVH

Download         Length: 360 bp

>AT168895 NZ_CP076254:3449790-3450083 [Xanthomonas translucens pv. graminis]
ATGACCGAAAACCTGACCACCTACGATCCTGCCGAGGATCTGAACTCCGACCAGGCGATTGCCGATTTCATGGCGGGCGC
CTTTGCGACCAACGACACCGGCTTCATCGCCCATGCCCTCGGCATCGTCGCCCGTGCCAAGGGCATGACCCAGATCGCAC
GACAAACCGGCCTGTCCCGGGAGCAGCTCTACCGCTCCTTCAGCGAGGACGGAAATCCGACGCTGCGCACCACCCTGGCC
GTCATGAAGGCGCTCGGGATCGAACTGACGGCCAAAGCCGCCGTCACGCATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A2RCL2

Antitoxin

Source ID Structure
AlphaFold DB J7U1S9

References