168878

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1946419..1947038 Replicon chromosome
Accession NZ_CP059468
Organism Klebsiella pneumoniae strain BA25665

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag HBJ46_RS09270 Protein ID WP_002892050.1
Coordinates 1946419..1946637 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag HBJ46_RS09275 Protein ID WP_002892066.1
Coordinates 1946664..1947038 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HBJ46_RS09235 (1942466) 1942466..1942729 + 264 WP_002892011.1 type B 50S ribosomal protein L31 -
HBJ46_RS09240 (1942729) 1942729..1942869 + 141 WP_002892018.1 type B 50S ribosomal protein L36 -
HBJ46_RS09245 (1942866) 1942866..1943564 - 699 WP_004178762.1 GNAT family protein -
HBJ46_RS09250 (1943665) 1943665..1945116 + 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
HBJ46_RS09255 (1945091) 1945091..1945561 - 471 WP_002892026.1 YlaC family protein -
HBJ46_RS09260 (1945582) 1945582..1945722 + 141 WP_004147370.1 hypothetical protein -
HBJ46_RS09265 (1945694) 1945694..1946260 - 567 WP_002892030.1 maltose O-acetyltransferase -
HBJ46_RS09270 (1946419) 1946419..1946637 - 219 WP_002892050.1 HHA domain-containing protein Toxin
HBJ46_RS09275 (1946664) 1946664..1947038 - 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
HBJ46_RS09280 (1947524) 1947524..1950670 - 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
HBJ46_RS09285 (1950693) 1950693..1951886 - 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T168878 WP_002892050.1 NZ_CP059468:c1946637-1946419 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T168878 NZ_CP076251:c1131606-1131349 [Xanthomonas translucens pv. phlei]
GTGACGCTTCAGTTCTCGGACAATGCTTGGGAGGACTACCTCTACTGGCAGCAGACCGACAAGAAGATGCTCAAGCGCAT
CAATGACCTGATCAAAGCCATCCAACACGATCCCTTCCAGGGCGTCGGCAAGCCAGAACCGCTGCGCCATGCCTTGGCCG
GCTATTGGTCGCGGCGCATCAACGACGAACACCGCATCGTGTACAAGGTCGAGGCGGGCGTCCTGCTGATCGCGCAGGTG
CGCTACCACTACGTGTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT168878 WP_002892066.1 NZ_CP059468:c1947038-1946664 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT168878 NZ_CP076251:c1131854-1131603 [Xanthomonas translucens pv. phlei]
ATGGACACCATCACCTATAGCGCTGCACGCGCCGCCCTCGCGGACACCATGGAGCGCGTCGTCAACAACCACGAGCCGGT
GATCATCACCCGCAGCCGCGAGCAATCCGTGGTCATGCTGTCGCTTGAGGACTACAAGGCGATGGAGGAAACCGCCTACC
TGCTCCGCAGTCCGAAGAGCGCGCAGCGCCTGCTGGAATCCATCGCCCAGCTCGAGGCCGGTCGCGGCAAGGCACGGGAC
CTGGCCGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References