168876

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1241386..1241902 Replicon chromosome
Accession NZ_CP059468
Organism Klebsiella pneumoniae strain BA25665

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag HBJ46_RS05995 Protein ID WP_004178374.1
Coordinates 1241618..1241902 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag HBJ46_RS05990 Protein ID WP_002886901.1
Coordinates 1241386..1241628 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HBJ46_RS05975 (1237414) 1237414..1238154 + 741 WP_002886899.1 KDGP aldolase family protein -
HBJ46_RS05980 (1238221) 1238221..1239375 + 1155 WP_004178372.1 lactonase family protein -
HBJ46_RS05985 (1239398) 1239398..1241308 + 1911 WP_004178373.1 PRD domain-containing protein -
HBJ46_RS05990 (1241386) 1241386..1241628 + 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HBJ46_RS05995 (1241618) 1241618..1241902 + 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HBJ46_RS06000 (1241906) 1241906..1242370 - 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
HBJ46_RS06005 (1242611) 1242611..1244749 - 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
HBJ46_RS06010 (1245106) 1245106..1245849 - 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
HBJ46_RS06015 (1245852) 1245852..1246025 - 174 WP_032408826.1 hypothetical protein -
HBJ46_RS06020 (1246110) 1246110..1246418 + 309 WP_004178377.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T168876 WP_004178374.1 NZ_CP059468:1241618-1241902 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T168876 NZ_CP076250:3584464-3584763 [Xanthomonas translucens pv. poae]
ATGACCATGACCGAAAACCTGACCACCTACGATCCTGCCGAGGATCTGAACTCCGACCAGGCGATTGCCGATTTCATGGC
GGGCGCCTTTGCGACCAACGACACCGGCTTCATCGCCCATGCCCTCGGCATCGTCGCCCGTGCCAAGGGCATGACCCAGA
TCGCACGACAAACCGGCCTGTCCCGGGAGCAGCTCTACCGCTCCTTCAGCGAGGACGGAAATCCGACGCTGCGCACTACC
CTGGCCGTCATGAAGGCGCTCGGGATCGAACTGACGGCCAAAGCCGCCGTCACGCATTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT168876 WP_002886901.1 NZ_CP059468:1241386-1241628 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT168876 NZ_CP076250:3584171-3584467 [Xanthomonas translucens pv. poae]
GTGATCGAACTCAAACAGACCGAGACGTTCCGCAAGTGGCGCACGAAGCTGAAGGACGAGCGCGCTCGCACTGCGATTGC
CTTGCGCTTGACCCGACTTGCCTATGGCCATGCCGGCGATACGGAAGCTGTCGGGCAAGGCATCAGCGAGCTGCGTATCC
ACCATGGCCCCGGATATCGGGTGTATTTCCAGCGGCGCGGCGACACGATCATCGTCTTGCTCTGCGGTGGCGACAAAAGC
ACGCAGGCAAAGGACATCAAGACAGCCAAACGGCTTGCCGACGAATGGAGCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References