Detailed information of TA system TA168875

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 1084522..1086203
• Replicon: chromosome
• Accession: NZ_CP059468
• Organism: Klebsiella pneumoniae strain BA25665

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: -
• Locus tag: HBJ46_RS05200
• Protein ID: WP_004178299.1
• Coordinates: 1085286..1086203 (+)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A6TH05
• Locus tag: HBJ46_RS05195
• Protein ID: WP_004177809.1
• Coordinates: 1084522..1085280 (+)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HBJ46_RS05180 (1080372)	1080372..1081058	-	687	WP_004151733.1	tetratricopeptide repeat protein	-
HBJ46_RS05185 (1081288)	1081288..1083435	-	2148	WP_012737173.1	formate dehydrogenase H subunit alpha, selenocysteine-containing	-
HBJ46_RS05190 (1083708)	1083708..1084436	+	729	WP_004178298.1	response regulator transcription factor	-
HBJ46_RS05195 (1084522)	1084522..1085280	+	759	WP_004177809.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
HBJ46_RS05200 (1085286)	1085286..1086203	+	918	WP_004178299.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
HBJ46_RS05205 (1086328)	1086328..1087335	-	1008	WP_004178300.1	carbohydrate kinase family protein	-
HBJ46_RS05210 (1087410)	1087410..1088351	-	942	WP_002885156.1	ABC transporter substrate-binding protein	-
HBJ46_RS05215 (1088382)	1088382..1089380	-	999	WP_002885172.1	ribose ABC transporter permease	-
HBJ46_RS05220 (1089377)	1089377..1090897	-	1521	WP_002885173.1	sugar ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34649.06 Da
• Isoelectric Point: 5.4707

>T168875 WP_004178299.1 NZ_CP059468:1085286-1086203 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPSQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

>T168875 NZ_CP076250:3584171-3584467 [Xanthomonas translucens pv. poae]
GTGATCGAACTCAAACAGACCGAGACGTTCCGCAAGTGGCGCACGAAGCTGAAGGACGAGCGCGCTCGCACTGCGATTGC
CTTGCGCTTGACCCGACTTGCCTATGGCCATGCCGGCGATACGGAAGCTGTCGGGCAAGGCATCAGCGAGCTGCGTATCC
ACCATGGCCCCGGATATCGGGTGTATTTCCAGCGGCGCGGCGACACGATCATCGTCTTGCTCTGCGGTGGCGACAAAAGC
ACGCAGGCAAAGGACATCAAGACAGCCAAACGGCTTGCCGACGAATGGAGCGAATGA

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28548.92 Da
• Isoelectric Point: 10.0870

>AT168875 WP_004177809.1 NZ_CP059468:1084522-1085280 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

>AT168875 NZ_CP076250:3584464-3584763 [Xanthomonas translucens pv. poae]
ATGACCATGACCGAAAACCTGACCACCTACGATCCTGCCGAGGATCTGAACTCCGACCAGGCGATTGCCGATTTCATGGC
GGGCGCCTTTGCGACCAACGACACCGGCTTCATCGCCCATGCCCTCGGCATCGTCGCCCGTGCCAAGGGCATGACCCAGA
TCGCACGACAAACCGGCCTGTCCCGGGAGCAGCTCTACCGCTCCTTCAGCGAGGACGGAAATCCGACGCTGCGCACTACC
CTGGCCGTCATGAAGGCGCTCGGGATCGAACTGACGGCCAAAGCCGCCGTCACGCATTGA

Structures

Antitoxin

• AlphaFold DB: A6TH05