Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 3725902..3726485 Replicon chromosome
Accession NZ_CP059467
Organism Aromatoleum bremense strain PbN1

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag pbN1_RS17485 Protein ID WP_169203204.1
Coordinates 3725902..3726090 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag pbN1_RS17490 Protein ID WP_169203203.1
Coordinates 3726096..3726485 (+) Length 130 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
pbN1_RS17455 (pbN1_35440) 3721392..3723275 + 1884 WP_244857004.1 nucleoside-diphosphate sugar epimerase/dehydratase -
pbN1_RS17460 3723505..3723753 + 249 WP_169203207.1 hypothetical protein -
pbN1_RS17465 (pbN1_35460) 3723763..3724719 + 957 WP_169203206.1 hypothetical protein -
pbN1_RS17470 (pbN1_35470) 3725002..3725301 + 300 WP_244857005.1 BrnT family toxin -
pbN1_RS17475 (pbN1_35480) 3725291..3725611 + 321 WP_244857007.1 type II toxin-antitoxin system MqsA family antitoxin -
pbN1_RS17480 (pbN1_35490) 3725689..3725775 + 87 Protein_3432 glucose-1-phosphate thymidylyltransferase -
pbN1_RS17485 (pbN1_35500) 3725902..3726090 + 189 WP_169203204.1 type II toxin-antitoxin system HicA family toxin Toxin
pbN1_RS17490 (pbN1_35510) 3726096..3726485 + 390 WP_169203203.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
pbN1_RS17495 (pbN1_35520) 3726626..3726829 + 204 WP_169203202.1 hypothetical protein -
pbN1_RS17500 (pbN1_35530) 3726900..3727181 + 282 WP_169203201.1 nucleotidyltransferase domain-containing protein -
pbN1_RS17505 (pbN1_35550) 3727497..3727841 + 345 WP_210147561.1 VanZ family protein -
pbN1_RS17510 (pbN1_35560) 3727882..3729438 + 1557 WP_210147562.1 ATP-binding protein -
pbN1_RS17515 (pbN1_35580) 3729690..3730025 + 336 WP_169204263.1 H-NS histone family protein -
pbN1_RS17520 (pbN1_35590) 3730000..3730428 + 429 WP_210147784.1 hypothetical protein -
pbN1_RS17525 (pbN1_35600) 3730428..3730616 + 189 WP_169204264.1 DUF4160 domain-containing protein -
pbN1_RS20855 (pbN1_35610) 3730613..3731107 + 495 WP_169204265.1 DUF2442 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3721371..3740643 19272


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-122)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7141.24 Da        Isoelectric Point: 11.1468

>T168869 WP_169203204.1 NZ_CP059467:3725902-3726090 [Aromatoleum bremense]
MKSTDIIKRLESEGWQRVGGKGDHIKFKHPGKPGHVVVPHPRKDVAIGTLRNIYRQAGWDWR

Download         Length: 189 bp

>T168869 NZ_CP076249:4126784-4128040 [Xanthomonas translucens pv. hordei]
ATGAAAGGAAAGATAAGTAATGCATGCAAGCCAGACATCACTCCCATTCTTGTGGATGGCTTAGCATCGACAGCAACGCA
AGGTGCCGCAGATGACTCGGCTTCCAGGCTGCCACAGCAGGCGTTGCTTGATGGTCTGCAGGAAAGGCCGCAGGCCCTTA
AAAAATCCAATTCGGCCGATTGGTCTGCTCGCACTCTCCCGCAATGGGCGCCGGGTCCAGGGACATCATCAAAAGCCCTG
CTGATCCAATCGCCTCCTCACCCCACAAGTTCAGACGAGATGTTTGGACTGGGTGAGCTTCCAGCGCCCGGAAAAGCCCG
ATGGGAATATCTTACGAAAACCGAGAACTGGCATCCAGAGCGCCAGGAATTGCATAGCCGGCTATTGAGCCAAGCACGAA
CTGCATCCCTGCGCTTGGCCGAATCAATTGAGAGCGACGGCTACCCACCAACATTGTTCGCATTACGAGGCAATACTGCC
ACTGGTAAGACGCGTATAGCGACAAAGACGATTCCTGTGCTCGCAAATGCGCTCAAGAAGAGCAGTGGCGGCGGCTGCAT
TAATCCTGACATCTTTAAACGTTCACTAGCGGAATCGCAAGGAGAAGCAATGAAACTCAGTTCGGCGCAGGTACACGCCG
AATCATGCGTCCTCGCCGATCGGCTTGAAAACGAGCTTCGCTCGCAAAGGACCACAAGCGGTGCAATGGCCAGCATACTC
GTCGACAAACGACTGGCAAACACGCATGAGGTCGACAGCTACGTCAGTTTAGCCAAGGAGACAGGGCGCAAGGTCGAGTT
GTGCGATATCGATGCGCCTCTTGAGCGATCCCTTATGGGCGTACTTCAGAGAAGTCCGGGAGGTGATGATCCACGACCGC
CTTACGTGGCGGTTGCGAATGGATTTTCGACTGTCCGGAGCAACCGCTTAGATGTCATCGACAGGTTCCTGTCAAATCCA
ACCTTGGGAAGTTATCGCCTGTTCGGCACGAATGAAAAGGGTGAAAAAGTGATGGTTGCCAGCGTCGCCGATGGCGAACT
CAGCATTCACGACCCCCAGTTGTATGAGAGCATTACAGCTCCCGAGGACTTCAACTCGGGTGACAAAGGAGAACAGGTAA
TCGACACAGCGCTGATTGACCGTTTGAGCAACAGCATCGATGATCCAAAGCGTGCAACGGATGCACGTGCCGCCCTGGAG
AAATACAAGGGAATGACGTGGTCAAATGCTCTAGCGGCACACAGCTCATTGATCTGA

Antitoxin


Download         Length: 130 a.a.        Molecular weight: 14511.32 Da        Isoelectric Point: 4.7755

>AT168869 WP_169203203.1 NZ_CP059467:3726096-3726485 [Aromatoleum bremense]
MLYPVYVHKDEGSAYGLTFPDFPGCFSAADELADLPRMAQEAVEVHFEGENMAIPKPSAPEQWGDDERFHGGYWMLVEID
LARVSARPVRLNISLPEYLVRQIDAYAASHHQSRSGFLARAAEEAMRAR

Download         Length: 390 bp

>AT168869 NZ_CP076249:4128054-4128350 [Xanthomonas translucens pv. hordei]
ATGACCCACTTAAAAGGCGCAGATGCACTTGCCCTGCATAAGAAACTCAAGGAGCGCAATGCCTCATTACGCAGTGCCGA
ACTTGATTCAGCAAAGGCGCTAGCCCATGAAAGCGGCAAAGAGCGCTTCAACCTCGAAAAATTGGAGAGCATTTGCGACA
CCACTCAAGCAGGGCGCATTACCGACCCGAACGATCGTCAGGCCATTTACGAACAAATGTATTATGTCGAGCATCCCAAA
GTCAGCACCTTGCAAGAATTCGCCCGCATTGTGGTGACGATTTCCTCATGGTCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References