Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-MazE
Location 1657006..1657556 Replicon chromosome
Accession NZ_CP059467
Organism Aromatoleum bremense strain PbN1

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag pbN1_RS07890 Protein ID WP_210147694.1
Coordinates 1657230..1657556 (+) Length 109 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag pbN1_RS07885 Protein ID WP_169202209.1
Coordinates 1657006..1657230 (+) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
pbN1_RS07875 (pbN1_15980) 1652399..1652818 + 420 WP_169120474.1 DedA family protein -
pbN1_RS07880 (pbN1_16000) 1653019..1656918 + 3900 WP_169202208.1 FAD/FMN-binding oxidoreductase -
pbN1_RS07885 (pbN1_16010) 1657006..1657230 + 225 WP_169202209.1 antitoxin MazE family protein Antitoxin
pbN1_RS07890 (pbN1_16020) 1657230..1657556 + 327 WP_210147694.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
pbN1_RS07895 (pbN1_16030) 1657667..1658653 - 987 WP_169202210.1 hypothetical protein -
pbN1_RS07900 (pbN1_16040) 1658831..1659565 - 735 WP_169204293.1 IS21-like element helper ATPase IstB -
pbN1_RS07905 (pbN1_16050) 1659633..1661192 - 1560 WP_169204294.1 IS21 family transposase -
pbN1_RS07910 (pbN1_16060) 1661336..1662073 + 738 WP_280516185.1 SDR family oxidoreductase -
pbN1_RS07915 (pbN1_16070) 1662101..1662337 - 237 WP_003296516.1 helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1607022..1761069 154047


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-103)

Antitoxin

Antitoxin MazE-like

(8-72)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 11455.48 Da        Isoelectric Point: 8.0236

>T168865 WP_210147694.1 NZ_CP059467:1657230-1657556 [Aromatoleum bremense]
MMRGDFVTIAMQGDFGKPGLALVIQADPFSEHATVTVLPVTSALVAAPLFRITVQPSAENGLQKPSQVMADKAITVKRAK
IGQAFGRIDADAMVEVERCLAVFLGIAK

Download         Length: 327 bp

>T168865 NZ_CP076249:c1068988-1068731 [Xanthomonas translucens pv. hordei]
GTGACGCTTCAGTTCTCGGACAATGCCTGGGAGGACGACCTCTACTGGCAGCAGACCGACAAGAAGATGCTCAAGCGCAT
CAACGACCTGATCAAAGCCATTCAACGCGATCCCTTCCAGGGCGTCGGCAAGCCAGAACGGCTACGCCATGCCTTGGCCG
GCTATTGGTCGCGGCGCATCAACGACGAACACCGCATCGTCTACAAGGTCGAGGCCGGCATGCTGCTGATCGCGCAGGTG
CGCTACCACTACGTGTAG

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8511.54 Da        Isoelectric Point: 4.7639

>AT168865 WP_169202209.1 NZ_CP059467:1657006-1657230 [Aromatoleum bremense]
MANTPVNARVQKHRDALRMAGLRPVQIWVPDTRRPDFAEECRRQSRLAAEADMADTDMQHFMDEALADVDGWTE

Download         Length: 225 bp

>AT168865 NZ_CP076249:c1069236-1068985 [Xanthomonas translucens pv. hordei]
ATGGACACCATCACCTATAGCGCTGCACGCGCCGCCCTTGCGGACACCATGGAGCGTGTCGTCAACAATCACGAGCCGGT
GATCATCACCCGCAGCCGCGAGCAATCCGTGGTCATGCTGTCGCTGGAGGACTACAAGGCGATGGAGGAAACCGCCTACC
TGCTGCGCAGCCCGAAGAGCGCGCAGCGCCTGCTGGAATCCATCGCCCAGCTAGAGGCCGGTCGCGGCAAGGCACGGGAC
CTGGCCGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References