Detailed information of TA system TA168864

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/GNAT-DUF1778
• Location: 1333248..1334026
• Replicon: chromosome
• Accession: NZ_CP059467
• Organism: Aromatoleum bremense strain PbN1

Toxin (Protein)

• Gene name: tacT
• Uniprot ID: -
• Locus tag: pbN1_RS06355
• Protein ID: WP_169202974.1
• Coordinates: 1333523..1334026 (+)
• Length: 168 a.a.

Antitoxin (Protein)

• Gene name: tacA
• Uniprot ID: -
• Locus tag: pbN1_RS06350
• Protein ID: WP_169202975.1
• Coordinates: 1333248..1333526 (+)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
pbN1_RS06300	1328262..1328618	+	357	WP_244857180.1	type II toxin-antitoxin system prevent-host-death family antitoxin	-
pbN1_RS06305 (pbN1_12790)	1328564..1328902	-	339	WP_169202981.1	nucleotidyltransferase domain-containing protein	-
pbN1_RS06310 (pbN1_12800)	1328964..1329560	-	597	WP_244857181.1	GNAT family N-acetyltransferase	-
pbN1_RS06315 (pbN1_12810)	1329557..1329838	-	282	WP_169202980.1	DUF1778 domain-containing protein	-
pbN1_RS06320 (pbN1_12820)	1329978..1330634	+	657	WP_210147679.1	nucleotidyltransferase domain-containing protein	-
pbN1_RS06325 (pbN1_12830)	1330801..1331103	+	303	WP_169202979.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
pbN1_RS06330 (pbN1_12840)	1331106..1331390	+	285	WP_169202978.1	type II toxin-antitoxin system RelE/ParE family toxin	-
pbN1_RS06335 (pbN1_12850)	1331521..1331724	+	204	WP_011236957.1	type II toxin-antitoxin system VapB family antitoxin	-
pbN1_RS06340 (pbN1_12860)	1331721..1332104	+	384	WP_169202977.1	VapC toxin family PIN domain ribonuclease	-
pbN1_RS06345	1332196..1332801	-	606	WP_244857182.1	EAL domain-containing protein	-
pbN1_RS06350 (pbN1_12890)	1333248..1333526	+	279	WP_169202975.1	DUF1778 domain-containing protein	Antitoxin
pbN1_RS06355 (pbN1_12900)	1333523..1334026	+	504	WP_169202974.1	GNAT family N-acetyltransferase	Toxin
pbN1_RS06360 (pbN1_12910)	1334349..1335188	-	840	WP_169202973.1	NAD(+) diphosphatase	-
pbN1_RS06365 (pbN1_12920)	1335267..1336664	-	1398	WP_169202972.1	heavy metal sensor histidine kinase	-
pbN1_RS06370 (pbN1_12930)	1336661..1337341	-	681	WP_169202971.1	heavy metal response regulator transcription factor	-
pbN1_RS06375 (pbN1_12940)	1337652..1338977	+	1326	WP_169202970.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1331521..1340231	8710

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (41-142)

Antitoxin

• Vibrio phage ICP1, Orf50 (11-86)

Sequences

Toxin

Protein

• Length: 168 a.a.
• Molecular weight: 18204.91 Da
• Isoelectric Point: 7.3226

>T168864 WP_169202974.1 NZ_CP059467:1333523-1334026 [Aromatoleum bremense]
MSAAYEPICKLSAADAVEGFDCGQPALNKFLHQYALVNQKANSAQTYVCRSAGEVVGFYSLAVGSVDPESAPARVMKGLA
RHPVPVMILARLAVDKNHQSKGLGQALLKDALQRTAQAADIAGIRCLLVHAKDDAARQWYESWEFEPSQTDSYHLFLMLK
DLKALLT

Nucleotide

• Length: 504 bp

>T168864 NZ_CP076248:c4431930-4431778 [Xanthomonas translucens pv. hordei]
ATGAAGCGACTGTTCACCTTGACGATGCTGACCCTGTTTTGTGCAGGCATGCTGACCGGCTGCAACACCATGGCCGGCGC
CGGTAAGGACATGCAGAAGGCCGGCGATAAGGTGGAAACCAAGGCCGACGACTGTAAAGACGGCAAGTGCTGA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10366.90 Da
• Isoelectric Point: 10.7556

>AT168864 WP_169202975.1 NZ_CP059467:1333248-1333526 [Aromatoleum bremense]
MTTLNQSKTERIDVRASGPVKQLLQEAARACHKNVSEFLLDAGVTAANQALADRRRFVLNDEQWQAFQQALDRPVQAKPR
LKKLLTEPGVLR

Nucleotide

• Length: 279 bp

>AT168864 NZ_CP076248:c4431679-4431545 [Xanthomonas translucens pv. hordei]
ATGAAGCGTACTTTCGCGTGGATGCTGCTGGCGATGTTCTCGGTGGGCCTGCTGTCGGGCTGCAACACGGTTGCCGGTGC
CGGCAAGGACGTGAAGAGCGCCGGCGAGAAGGTCGAAGACGCCGCCAAGAACTGA