Detailed information of TA system TA168863

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 1331521..1332104
• Replicon: chromosome
• Accession: NZ_CP059467
• Organism: Aromatoleum bremense strain PbN1

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: pbN1_RS06340
• Protein ID: WP_169202977.1
• Coordinates: 1331721..1332104 (+)
• Length: 128 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: pbN1_RS06335
• Protein ID: WP_011236957.1
• Coordinates: 1331521..1331724 (+)
• Length: 68 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
pbN1_RS06295 (pbN1_12780)	1326989..1328155	+	1167	WP_169202982.1	sulfatase-like hydrolase/transferase	-
pbN1_RS06300	1328262..1328618	+	357	WP_244857180.1	type II toxin-antitoxin system prevent-host-death family antitoxin	-
pbN1_RS06305 (pbN1_12790)	1328564..1328902	-	339	WP_169202981.1	nucleotidyltransferase domain-containing protein	-
pbN1_RS06310 (pbN1_12800)	1328964..1329560	-	597	WP_244857181.1	GNAT family N-acetyltransferase	-
pbN1_RS06315 (pbN1_12810)	1329557..1329838	-	282	WP_169202980.1	DUF1778 domain-containing protein	-
pbN1_RS06320 (pbN1_12820)	1329978..1330634	+	657	WP_210147679.1	nucleotidyltransferase domain-containing protein	-
pbN1_RS06325 (pbN1_12830)	1330801..1331103	+	303	WP_169202979.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
pbN1_RS06330 (pbN1_12840)	1331106..1331390	+	285	WP_169202978.1	type II toxin-antitoxin system RelE/ParE family toxin	-
pbN1_RS06335 (pbN1_12850)	1331521..1331724	+	204	WP_011236957.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
pbN1_RS06340 (pbN1_12860)	1331721..1332104	+	384	WP_169202977.1	VapC toxin family PIN domain ribonuclease	Toxin
pbN1_RS06345	1332196..1332801	-	606	WP_244857182.1	EAL domain-containing protein	-
pbN1_RS06350 (pbN1_12890)	1333248..1333526	+	279	WP_169202975.1	DUF1778 domain-containing protein	-
pbN1_RS06355 (pbN1_12900)	1333523..1334026	+	504	WP_169202974.1	GNAT family N-acetyltransferase	-
pbN1_RS06360 (pbN1_12910)	1334349..1335188	-	840	WP_169202973.1	NAD(+) diphosphatase	-
pbN1_RS06365 (pbN1_12920)	1335267..1336664	-	1398	WP_169202972.1	heavy metal sensor histidine kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1331521..1340231	8710
	-	flank	IS/Tn	-	-	1325700..1326869	1169

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (1-43)

Sequences

Toxin

Protein

• Length: 128 a.a.
• Molecular weight: 14194.67 Da
• Isoelectric Point: 5.1183

>T168863 WP_169202977.1 NZ_CP059467:1331721-1332104 [Aromatoleum bremense]
MKGVLVDTSVWVDHFRQRNDVLVDLLDLDLALTHPMVLVELACGTPPAPRVRTLSDIGLLQQTQQASLREVMDFIEREKL
YGLGCGLVDMVLLASTLITPGAELWTLDKRLVALSERFGVMHRSILQ

Nucleotide

• Length: 384 bp

>T168863 NZ_CP076248:c4431679-4431545 [Xanthomonas translucens pv. hordei]
ATGAAGCGTACTTTCGCGTGGATGCTGCTGGCGATGTTCTCGGTGGGCCTGCTGTCGGGCTGCAACACGGTTGCCGGTGC
CGGCAAGGACGTGAAGAGCGCCGGCGAGAAGGTCGAAGACGCCGCCAAGAACTGA

Antitoxin

Protein

• Length: 68 a.a.
• Molecular weight: 7567.67 Da
• Isoelectric Point: 5.0490

>AT168863 WP_011236957.1 NZ_CP059467:1331521-1331724 [Aromatoleum bremense]
MRTTVTIDDDLYEKALEVADPAMDRADLFREAMKTFVRVQAAKRLAALGGTMPEMQDVPRRRGEPSQ

Nucleotide

• Length: 204 bp

>AT168863 NZ_CP076248:c4431930-4431778 [Xanthomonas translucens pv. hordei]
ATGAAGCGACTGTTCACCTTGACGATGCTGACCCTGTTTTGTGCAGGCATGCTGACCGGCTGCAACACCATGGCCGGCGC
CGGTAAGGACATGCAGAAGGCCGGCGATAAGGTGGAAACCAAGGCCGACGACTGTAAAGACGGCAAGTGCTGA