Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-vapB/-
Location 1331106..1331724 Replicon chromosome
Accession NZ_CP059467
Organism Aromatoleum bremense strain PbN1

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag pbN1_RS06330 Protein ID WP_169202978.1
Coordinates 1331106..1331390 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag pbN1_RS06335 Protein ID WP_011236957.1
Coordinates 1331521..1331724 (+) Length 68 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
pbN1_RS06295 (pbN1_12780) 1326989..1328155 + 1167 WP_169202982.1 sulfatase-like hydrolase/transferase -
pbN1_RS06300 1328262..1328618 + 357 WP_244857180.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
pbN1_RS06305 (pbN1_12790) 1328564..1328902 - 339 WP_169202981.1 nucleotidyltransferase domain-containing protein -
pbN1_RS06310 (pbN1_12800) 1328964..1329560 - 597 WP_244857181.1 GNAT family N-acetyltransferase -
pbN1_RS06315 (pbN1_12810) 1329557..1329838 - 282 WP_169202980.1 DUF1778 domain-containing protein -
pbN1_RS06320 (pbN1_12820) 1329978..1330634 + 657 WP_210147679.1 nucleotidyltransferase domain-containing protein -
pbN1_RS06325 (pbN1_12830) 1330801..1331103 + 303 WP_169202979.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
pbN1_RS06330 (pbN1_12840) 1331106..1331390 + 285 WP_169202978.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
pbN1_RS06335 (pbN1_12850) 1331521..1331724 + 204 WP_011236957.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
pbN1_RS06340 (pbN1_12860) 1331721..1332104 + 384 WP_169202977.1 VapC toxin family PIN domain ribonuclease -
pbN1_RS06345 1332196..1332801 - 606 WP_244857182.1 EAL domain-containing protein -
pbN1_RS06350 (pbN1_12890) 1333248..1333526 + 279 WP_169202975.1 DUF1778 domain-containing protein -
pbN1_RS06355 (pbN1_12900) 1333523..1334026 + 504 WP_169202974.1 GNAT family N-acetyltransferase -
pbN1_RS06360 (pbN1_12910) 1334349..1335188 - 840 WP_169202973.1 NAD(+) diphosphatase -
pbN1_RS06365 (pbN1_12920) 1335267..1336664 - 1398 WP_169202972.1 heavy metal sensor histidine kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1325700..1326869 1169


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-92)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-43)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10394.11 Da        Isoelectric Point: 5.8335

>T168862 WP_169202978.1 NZ_CP059467:1331106-1331390 [Aromatoleum bremense]
MGIVWTEEAIGDLEEILAYYYAEAGPATAQAVQERLVTEIVALTTFPERIRTSGRVPGARELVVRRLPYVVFVKVVPAGV
VVLNVVHTARKFPE

Download         Length: 285 bp

>T168862 NZ_CP076248:4139371-4140627 [Xanthomonas translucens pv. hordei]
ATGAAAGGAAAGATAAGTAATGCATGCAAGCCAGACATCACTCCCATTCTTGTGGATGGCTTAGCATCGACAGCAACGCA
AGGTGCCGCAGATGACTCGGCTTCCAGGCTGCCACAGCAGGCGTTGCTTGATGGTCTGCAGGAAAGGCCGCAGGCCCTTA
AAAAATCCAATTCGGCCGATTGGTCTGCTCGCACTCTCCCGCAATGGGCGCCGGGTCCAGGGACATCATCAAAAGCCCTG
CTGATCCAATCGCCTCCTCACCCCACAAGTTCAGACGAGATGTTTGGACTGGGTGAGCTTCCAGCGCCCGGAAAAGCCCG
ATGGGAATATCTTACGAAAACCGAGAACTGGCATCCAGAGCGCCAGGAATTGCATAGCCGGCTATTGAGCCAAGCACGAA
CTGCATCCCTGCGCTTGGCCGAATCAATTGAGAGCGACGGCTACCCACCAACATTGTTCGCATTACGAGGCAATACTGCC
ACTGGTAAGACGCGTATAGCGACAAAGACGATTCCTGTGCTCGCAAATGCGCTCAAGAAGAGCAGTGGCGGCGGCTGCAT
TAATCCTGACATCTTTAAACGTTCACTAGCGGAATCGCAAGGAGAAGCAATGAAACTCAGTTCGGCGCAGGTACACGCCG
AATCATGCGTCCTCGCCGATCGGCTTGAAAACGAGCTTCGCTCGCAAAGGACCACAAGCGGTGCAATGGCCAGCATACTC
GTCGACAAACGACTGGCAAACACGCATGAGGTCGACAGCTACGTCAGTTTAGCCAAGGAGACAGGGCGCAAGGTCGAGTT
GTGCGATATCGATGCGCCTCTTGAGCGATCCCTTATGGGCGTACTTCAGAGAAGTCCGGGAGGTGATGATCCACGACCGC
CTTACGTGGCGGTTGCGAATGGATTTTCGACTGTCCGGAGCAACCGCTTAGATGTCATCGACAGGTTCCTGTCAAATCCA
ACCTTGGGAAGTTATCGCCTGTTCGGCACGAATGAAAAGGGTGAAAAAGTGATGGTTGCCAGCGTCGCCGATGGCGAACT
CAGCATTCACGACCCCCAGTTGTATGAGAGCATTACAGCTCCCGAGGACTTCAACTCGGGTGACAAAGGAGAACAGGTAA
TCGACACAGCGCTGATTGACCGTTTGAGCAACAGCATCGATGATCCAAAGCGTGCAACGGATGCACGTGCCGCCCTGGAG
AAATACAAGGGAATGACGTGGTCAAATGCTCTAGCGGCACACAGCTCATTGATCTGA

Antitoxin


Download         Length: 68 a.a.        Molecular weight: 7567.67 Da        Isoelectric Point: 5.0490

>AT168862 WP_011236957.1 NZ_CP059467:1331521-1331724 [Aromatoleum bremense]
MRTTVTIDDDLYEKALEVADPAMDRADLFREAMKTFVRVQAAKRLAALGGTMPEMQDVPRRRGEPSQ

Download         Length: 204 bp

>AT168862 NZ_CP076248:4140641-4140937 [Xanthomonas translucens pv. hordei]
ATGACCCACTTAAAAGGCGCAGATGCACTTGCCCTGCATAAGAAACTCAAGGAGCGCAATGCCTCATTACGCAGTGCCGA
ACTTGATTCAGCAAAGGCGCTAGCCCATGAAAGCGGCAAAGAGCGCTTCAACCTCGAAAAATTGGAGAGCATTTGCGACA
CCACTCAAGCAGGGCGCATTACCGACCCGAACGATCGTCAGGCCATTTACGAACAAATGTATTATGTCGAGCATCCCAAA
GTCAGCACCTTGCAAGAATTCGCCCGCATTGTGGTGACGATTTCCTCATGGTCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References