Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 3564887..3565563 Replicon chromosome
Accession NZ_CP059447
Organism Cellulosimicrobium cellulans strain 2020WEIHUA_E

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag H1Q78_RS15735 Protein ID WP_237841075.1
Coordinates 3565153..3565563 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag H1Q78_RS15730 Protein ID WP_237841074.1
Coordinates 3564887..3565156 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1Q78_RS15700 (H1Q78_15660) 3560289..3560684 + 396 WP_237841070.1 response regulator -
H1Q78_RS15705 (H1Q78_15665) 3560681..3561043 + 363 WP_237841071.1 Hpt domain-containing protein -
H1Q78_RS15710 (H1Q78_15670) 3561162..3561434 + 273 WP_237841072.1 hypothetical protein -
H1Q78_RS15715 (H1Q78_15675) 3561606..3561860 + 255 WP_082140876.1 helix-turn-helix transcriptional regulator -
H1Q78_RS15720 (H1Q78_15680) 3561941..3562369 + 429 WP_141389727.1 (deoxy)nucleoside triphosphate pyrophosphohydrolase -
H1Q78_RS15725 (H1Q78_15685) 3562510..3564600 - 2091 WP_237841073.1 glycosyl hydrolase family 28-related protein -
H1Q78_RS15730 (H1Q78_15690) 3564887..3565156 + 270 WP_237841074.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
H1Q78_RS15735 (H1Q78_15695) 3565153..3565563 + 411 WP_237841075.1 type II toxin-antitoxin system VapC family toxin Toxin
H1Q78_RS15740 (H1Q78_15700) 3565635..3567491 + 1857 WP_237841076.1 lipase family protein -
H1Q78_RS15745 (H1Q78_15705) 3567656..3568048 - 393 WP_237841077.1 hypothetical protein -
H1Q78_RS15750 (H1Q78_15710) 3568191..3568613 + 423 WP_237841078.1 VOC family protein -
H1Q78_RS15755 (H1Q78_15715) 3568707..3570014 + 1308 WP_237841079.1 amidohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-125)

Antitoxin

Antitoxin VapB-like

(1-88)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 14740.70 Da        Isoelectric Point: 4.7722

>T168857 WP_237841075.1 NZ_CP059447:3565153-3565563 [Cellulosimicrobium cellulans]
VIVDTSAIVAVVLGEPGADTLSEILLAANRPRMAAPTLVELYAVLDNRSSPAQRRRLDALLELYGIEVEPFTAEHAEIAR
EAYREFGRGSGHPARLNLGDCFAYALAAATRDRLLFVGDDFSRTDLRPAHEAAPPV

Download         Length: 411 bp

>T168857 NZ_CP076247:c2388-1348 [Escherichia coli O157:H7]
ATGGCACAGAACCCGTTTAAAGCACTAAATATCAATATTGACAAGATTGAGTCTGCTCTGACGCAGAATGGCGTCACAAA
CTATTCCTCTAATGTAAAAAACGAAAGAGAAACTCACATATCTGGCACATATAAAGGAATAGACTTCTTAATAAAACTAA
TGCCATCAGGCGGAAATACCACTATCGGAAGAGCGTCTGGGCAAAATAACACTTACTTTGATGAAATCGCCTTGATTATA
AAAGAAAACTGTTTGTATTCAGACACAAAGAACTTTGAATACACCATTCCAAAATTCAGTGATGATGACAGGGCAAATCT
ATTTGAATTTCTTTCTGAAGAGGGGATAACAATAACAGAAGATAATAATAACGATCCTAATTGTAAACACCAATATATTA
TGACCACCAGCAATGGTGACAGGGTCAGGGCAAAAATTTACAAGCGCGGCTCTATTCAATTCCAAGGAAAATACCTTCAA
ATCGCGAGTTTGATTAACGATTTCATGTGCTCAATACTAAACATGAAAGAGATTGTCGAACAAAAAAATAAAGAATTTAA
TGTTGACATAAAAAAAGAAACTATTGAGTCCGAGTTGCATAGCAAACTACCAAAAAGCATCGATAAAATCCATGAAGATA
TCAAAAAACAGCTATCATGCTCGCTAATAATGAAAAAAATAGATGTCGAAATGGAAGATTACTCAACATACTGCTTCTCT
GCATTAAGAGCCATAGAAGGCTTTATATATCAAATACTTAATGATGTTTGCAATCCATCATCATCAAAGAACCTTGGCGA
ATACTTCACTGAAAACAAACCCAAATATATAATCAGAGAAATACACCAAGAAACTATAAATGGTGAAATAGCGGAAGTTT
TGTGTGAATGCTACACTTACTGGCATGAGAACAGGCATGGTTTGTTTCATATGAAACCAGGAATAGCTGACACGAAGACA
ATTAACAAATTAGAATCAATCGCAATCATCGATACCGTTTGCCAATTAATAGATGGTGGCGTAGCTAGGTTGAAATTATG
A

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9951.09 Da        Isoelectric Point: 4.9310

>AT168857 WP_237841074.1 NZ_CP059447:3564887-3565156 [Cellulosimicrobium cellulans]
MSLNIKNERTHALVRRLAETTGQSQTSAIEEAVQHRLDEVLESRSRGDEAVAARRAEIARLLDEIRVDLDVDGVRAAEAA
LYDERGLPR

Download         Length: 270 bp

>AT168857 NZ_CP076247:c1351-971 [Escherichia coli O157:H7]
ATGAAAAAAGATAAAAAATATCAAATAGAAGCAATAAAAAATAAAGATAAAACTTTATTTATTGTCTATGCTACTGATAT
TTATAGCCCGAGCGAATTTTTCTCAAAAATCGAATCCGACTTGAAGAAAAAGAAAAGCAAGGGTGATGTTTTTTTTGATT
TAATAATTCCTAACGGTGGAAAAAAAGATCGTTACGTCTATACGTCATTTAATGGCGAGAAGTTTTCAAGTTACACATTA
AACAAAGTTACGAAAACTGATGAATATAATGATTTATCTGAGCTCTCGGCTTCGTTCTTTAAAAAAAACTTTGATAAGAT
CAACGTAAACCTTCTATCCAAAGCCACATCATTTGCTTTGAAAAAAGGCATTCCAATATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References