Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2646127..2646779 Replicon chromosome
Accession NZ_CP059447
Organism Cellulosimicrobium cellulans strain 2020WEIHUA_E

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag H1Q78_RS11680 Protein ID WP_237840386.1
Coordinates 2646357..2646779 (+) Length 141 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag H1Q78_RS11675 Protein ID WP_141391028.1
Coordinates 2646127..2646360 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1Q78_RS11660 (H1Q78_11625) 2643134..2643688 - 555 WP_237840384.1 hypoxanthine phosphoribosyltransferase -
H1Q78_RS11665 (H1Q78_11630) 2643798..2644847 - 1050 Protein_2293 tRNA lysidine(34) synthetase TilS -
H1Q78_RS11670 (H1Q78_11635) 2644852..2646045 - 1194 WP_237840385.1 zinc-dependent metalloprotease -
H1Q78_RS11675 (H1Q78_11640) 2646127..2646360 + 234 WP_141391028.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
H1Q78_RS11680 (H1Q78_11645) 2646357..2646779 + 423 WP_237840386.1 type II toxin-antitoxin system VapC family toxin Toxin
H1Q78_RS11685 (H1Q78_11650) 2646791..2648203 - 1413 WP_237843723.1 D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase -
H1Q78_RS11690 (H1Q78_11655) 2648450..2648953 + 504 WP_034655165.1 inorganic diphosphatase -
H1Q78_RS11695 (H1Q78_11660) 2649108..2650535 - 1428 WP_237840387.1 C40 family peptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 15236.35 Da        Isoelectric Point: 5.2305

>T168855 WP_237840386.1 NZ_CP059447:2646357-2646779 [Cellulosimicrobium cellulans]
VSPLYLLDTNVLIALLRGNGVAARPRLREAEGRVAVSTVSEMELEYGIERSDDPHRNRQAVDDLLSLVDVLPFDGLAAMH
AGRVRARLAARGTPIGPYDALLAGHARSLGLVMVTNNVREFSRVPGLEVEDWLAEAPSDR

Download         Length: 423 bp

>T168855 NZ_CP076246:2066-2341 [Escherichia coli O157:H7]
ATGGAACTGAAGTGGAGCAGTAAAGCGCTTTCTGATTTGGCGCGGTTATATGATTTTCTGGTGCTAGCCAGTAAACCTGC
TGCCGCCAGAACGGTACAGTCCCTGACACAGGCACCGGTCATTCTGTTAACTCATCCACGTATGGGGGAACAGTTATTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTGCTGGCGAGTACGAAATCCGTTACGAACTTAATGGCCAGACTATTTAT
GTATTGCGCCTGTGGCACACACGAGAAAACAGGTAG

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8676.70 Da        Isoelectric Point: 5.8214

>AT168855 WP_141391028.1 NZ_CP059447:2646127-2646360 [Cellulosimicrobium cellulans]
MVRTTVFRSNRTQAVRLPKAVALPDDVREVEVRTVGRSRVITPAGTGWDEWFDHGLRVADDFLPDRDQGNAEERGAL

Download         Length: 234 bp

>AT168855 NZ_CP076246:1782-2066 [Escherichia coli O157:H7]
ATGCAAATGAAAAACAATACCGCACAAGCAACAAAAGTCATTACCGCGCATGTGCCATTACCTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGACTGGAACGCTCCCGGGGTTGGGTTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAGGAGGAGG
AGCGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGGTTATTGACCATCAGGCTGTACAGGCCTGG
GCGGACAGCCTCAGTACTGACAATCCGTTACCGGTGCCACGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References