Detailed information of TA system TA168852

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): fic-relB/Fic-Fic
• Location: 1211693..1213449
• Replicon: chromosome
• Accession: NZ_CP059445
• Organism: Campylobacter fetus strain CFF09A980

Toxin (Protein)

• Gene name: Fic
• Uniprot ID: A0A825B8P0
• Locus tag: GZ984_RS06070
• Protein ID: WP_059429739.1
• Coordinates: 1211693..1212613 (-)
• Length: 307 a.a.

Antitoxin (Protein)

• Gene name: Fic
• Uniprot ID: A0A825BG67
• Locus tag: GZ984_RS06075
• Protein ID: WP_059429738.1
• Coordinates: 1212613..1213449 (-)
• Length: 279 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GZ984_RS06045	1207393..1208832	-	1440	WP_059429744.1	PcfJ domain-containing protein	-
GZ984_RS06050	1208974..1209201	-	228	WP_059429743.1	hypothetical protein	-
GZ984_RS06055	1209518..1210081	+	564	WP_059429742.1	hypothetical protein	-
GZ984_RS06060	1210078..1211415	+	1338	WP_059429741.1	hypothetical protein	-
GZ984_RS06065	1211424..1211693	-	270	WP_059429740.1	hypothetical protein	-
GZ984_RS06070	1211693..1212613	-	921	WP_059429739.1	Fic family protein	Toxin
GZ984_RS06075	1212613..1213449	-	837	WP_059429738.1	Fic family protein	Antitoxin
GZ984_RS06080	1213616..1213936	-	321	Protein_1185	DUF86 domain-containing protein	-
GZ984_RS06085	1213929..1214243	-	315	WP_059429737.1	nucleotidyltransferase domain-containing protein	-
GZ984_RS06090	1214311..1214724	-	414	WP_181913227.1	ParA family protein	-
GZ984_RS06095	1214929..1215786	-	858	WP_003454325.1	aminoglycoside nucleotidyltransferase ANT(6)-Ib	-
GZ984_RS06100	1216101..1218023	-	1923	WP_003454408.1	tetracycline resistance ribosomal protection protein Tet(44)	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	ant(6)-Ib	-	1201040..1215786	14746

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Fido domain (91-202)

Antitoxin

• Fido domain (85-182)

Sequences

Toxin

Protein

• Length: 307 a.a.
• Molecular weight: 35602.38 Da
• Isoelectric Point: 8.4827

>T168852 WP_059429739.1 NZ_CP059445:c1212613-1211693 [Campylobacter fetus]
MQEQYTEIKDSNIINKQNIDIAVGLGLVDDLKPSEYFYKAVEKSRTYNELEDNVKKYYDGKKLDKKEVGEKECDIVSVNI
AKYLEKSGFTLSPVTLKTIHKNLFWDAFPQGLEKYVGVFRDVNISKKEEVLGGEKSVEYGNYDELGDMLDYDFDREKRKD
YTKMTRQEQALNVGKFVSGIWQIHPFREGNTRTIAVFTIKYLQSKGFEANNDIFKENSKYFRDALVLANYDNMKENIKSD
FSYLESFFNKFILNKNIELKLLPNSPKDYKSEKSVLSRLGAVYDKKVQSGAIKQPQISEKSKEKER

Nucleotide

• Length: 921 bp

>T168852 NZ_CP076245:4727524-4727865 [Escherichia coli O157:H7]
ATGACTGATACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGTTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGTGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGCCGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAGGCAGGTGCAGGAGTTTATTGGGGTGATTGC
GGGTAAACAGAAAGTTGCCTGA

Antitoxin

Protein

• Length: 279 a.a.
• Molecular weight: 31926.35 Da
• Isoelectric Point: 8.5962

>AT168852 WP_059429738.1 NZ_CP059445:c1213449-1212613 [Campylobacter fetus]
MDGGENLGNFLKNNNERDYWLDVCVRMAHHSTAIEGNTLSQDETASILLDGYIAKATSEREFYEVKNYRQILPKMFSSLQ
EKAKIDEKLIKDFHRLIMNNLIDNNGKFKTIENLVVGANFEPTKPYLVPVSIKDMCDNLYFRLDNAKNNDDKLKAILQSH
IKFEKIHPFSDGNGRTGRIIMIYGCLENNLAPIIIPKEQKNRYIAILRNNDIDGFMAFAKEIEKDEISRRNKFLSQRPNE
QDNSKSVLSRLSNAYAKKLESGAIKALNDTANSKEKER

Nucleotide

• Length: 837 bp

>AT168852 NZ_CP076245:c4727529-4727453 [Escherichia coli O157:H7]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Toxin

• AlphaFold DB: A0A825B8P0

Antitoxin

• AlphaFold DB: A0A825BG67