Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | fic-relB/Fic-Fic |
| Location | 32950..34706 | Replicon | plasmid pCFV_08A948_P1 |
| Accession | NZ_CP059442 | ||
| Organism | Campylobacter fetus strain CFV08A948-2A | ||
Toxin (Protein)
| Gene name | Fic | Uniprot ID | C5H2Y4 |
| Locus tag | GZ986_RS10335 | Protein ID | WP_002850956.1 |
| Coordinates | 32950..33870 (-) | Length | 307 a.a. |
Antitoxin (Protein)
| Gene name | Fic | Uniprot ID | B2CG46 |
| Locus tag | GZ986_RS10340 | Protein ID | WP_002850958.1 |
| Coordinates | 33870..34706 (-) | Length | 279 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GZ986_RS10310 | 28585..28998 | - | 414 | WP_046037538.1 | type II toxin-antitoxin system VapC family toxin | - |
| GZ986_RS10315 | 28995..29813 | - | 819 | WP_134853972.1 | hypothetical protein | - |
| GZ986_RS10320 | 30757..31338 | + | 582 | WP_002850948.1 | hypothetical protein | - |
| GZ986_RS10325 | 31335..32672 | + | 1338 | WP_035148452.1 | hypothetical protein | - |
| GZ986_RS10330 | 32681..32950 | - | 270 | WP_035148454.1 | hypothetical protein | - |
| GZ986_RS10335 | 32950..33870 | - | 921 | WP_002850956.1 | Fic family protein | Toxin |
| GZ986_RS10340 | 33870..34706 | - | 837 | WP_002850958.1 | Fic family protein | Antitoxin |
| GZ986_RS10345 | 34710..35012 | - | 303 | WP_080582791.1 | DUF86 domain-containing protein | - |
| GZ986_RS10350 | 35134..35445 | - | 312 | WP_002850963.1 | nucleotidyltransferase domain-containing protein | - |
| GZ986_RS10355 | 35513..36175 | - | 663 | WP_002850964.1 | AAA family ATPase | - |
| GZ986_RS10360 | 36310..37410 | - | 1101 | WP_166428600.1 | transposase | - |
| GZ986_RS10365 | 37388..37843 | - | 456 | WP_010404250.1 | IS200/IS605 family transposase | - |
| GZ986_RS10370 | 38209..38622 | - | 414 | WP_046037538.1 | type II toxin-antitoxin system VapC family toxin | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..38770 | 38770 | |
| - | flank | IS/Tn | - | - | 37388..37843 | 455 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 307 a.a. Molecular weight: 35445.26 Da Isoelectric Point: 9.2339
>T168850 WP_002850956.1 NZ_CP059442:c33870-32950 [Campylobacter fetus]
MQEQYTEIKDSNIINKQNIDIAVGLGLVDDLKPSEYFYKAVEKSRTYNELEDNVKKYYDGKKLDKKEVGEKECDIVSVNI
AKYLEKSGFTLSPVTLKTIHKNLFWDAFPQGLEKYVGVFRDVNISKKEEVLGGEKSVEYGNYDELGDMLDYDFDREKRKD
YAKMTRQEQALNVGKFVSGVWQIHPFREGNTRTIAVFTIKYLQSKGFEANNDIFKENSKYFRDALVLANYDNMKENIKSD
FSYLESFFNKFILNKNIELKLLPNSPKGHKSEKSVLSRLGAAYDKKVQSGAIKQPQISKKSKEKER
MQEQYTEIKDSNIINKQNIDIAVGLGLVDDLKPSEYFYKAVEKSRTYNELEDNVKKYYDGKKLDKKEVGEKECDIVSVNI
AKYLEKSGFTLSPVTLKTIHKNLFWDAFPQGLEKYVGVFRDVNISKKEEVLGGEKSVEYGNYDELGDMLDYDFDREKRKD
YAKMTRQEQALNVGKFVSGVWQIHPFREGNTRTIAVFTIKYLQSKGFEANNDIFKENSKYFRDALVLANYDNMKENIKSD
FSYLESFFNKFILNKNIELKLLPNSPKGHKSEKSVLSRLGAAYDKKVQSGAIKQPQISKKSKEKER
Download Length: 921 bp
>T168850 NZ_CP076245:c4373895-4373497 [Escherichia coli O157:H7]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAAGAGCTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACTTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAATCGCATTTGGTATATTGTCAGGGTGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAAGAGCTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACTTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAATCGCATTTGGTATATTGTCAGGGTGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA
Antitoxin
Download Length: 279 a.a. Molecular weight: 31851.33 Da Isoelectric Point: 8.5962
>AT168850 WP_002850958.1 NZ_CP059442:c34706-33870 [Campylobacter fetus]
MDGGVNLGNFLKNNNERDYWLDVCVRMAHHSTAIEGNTLSQDETASILLDGYIAKATSEREFYEVKNYRQILPKMFSSLQ
EKAKIDEKLIKDFHRLIMNNLIDNNGKFKTIENLVVGANFEPTKPYLVPVAIKDMCDNLYFRLDNAKNDDDKLKAILQSH
IKFEKIHPFSDGNGRTGRIIMIYGCLENNLAPIIIPKEQKNRYIAILRNNDIDGFMAFAKEIEKDEISRRNKFLSQRPNE
QDNSKSVLSRLGNAYAKKLESGAIKALNDTANSKEKER
MDGGVNLGNFLKNNNERDYWLDVCVRMAHHSTAIEGNTLSQDETASILLDGYIAKATSEREFYEVKNYRQILPKMFSSLQ
EKAKIDEKLIKDFHRLIMNNLIDNNGKFKTIENLVVGANFEPTKPYLVPVAIKDMCDNLYFRLDNAKNDDDKLKAILQSH
IKFEKIHPFSDGNGRTGRIIMIYGCLENNLAPIIIPKEQKNRYIAILRNNDIDGFMAFAKEIEKDEISRRNKFLSQRPNE
QDNSKSVLSRLGNAYAKKLESGAIKALNDTANSKEKER
Download Length: 837 bp
>AT168850 NZ_CP076245:c4374191-4373898 [Escherichia coli O157:H7]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAATTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGAGCT
GAAAAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAATTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGAGCT
GAAAAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7D7L3Y5 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7D7Q668 |