Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) FicTA/Fic(toxin)
Location 6974..7874 Replicon plasmid pCFV_08A948_P1
Accession NZ_CP059442
Organism Campylobacter fetus strain CFV08A948-2A

Toxin (Protein)


Gene name Fic Uniprot ID A0A7D7Q4U4
Locus tag GZ986_RS10180 Protein ID WP_065839018.1
Coordinates 6974..7645 (-) Length 224 a.a.

Antitoxin (Protein)


Gene name Fti Uniprot ID A0A7D7Q4X0
Locus tag GZ986_RS10185 Protein ID WP_046037523.1
Coordinates 7638..7874 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GZ986_RS10135 2044..2394 - 351 WP_002851003.1 hypothetical protein -
GZ986_RS10140 2391..2666 - 276 WP_035148435.1 type II toxin-antitoxin system YafQ family toxin -
GZ986_RS10145 2659..2874 - 216 WP_035148437.1 hypothetical protein -
GZ986_RS10150 3089..3457 + 369 WP_065842670.1 DNA transfer protein -
GZ986_RS10155 3432..4994 + 1563 WP_065842669.1 relaxase/mobilization nuclease domain-containing protein -
GZ986_RS10160 5074..5283 - 210 WP_040126369.1 hypothetical protein -
GZ986_RS10165 5287..5976 - 690 WP_065839021.1 AAA family ATPase -
GZ986_RS10170 6087..6458 - 372 WP_002850989.1 hypothetical protein -
GZ986_RS10175 6455..6913 - 459 WP_046037527.1 S26 family signal peptidase -
GZ986_RS10180 6974..7645 - 672 WP_065839018.1 Fic family protein Toxin
GZ986_RS10185 7638..7874 - 237 WP_046037523.1 hypothetical protein Antitoxin
GZ986_RS10190 7991..8698 - 708 WP_002850984.1 conjugal transfer protein TraL -
GZ986_RS10195 8710..10536 - 1827 WP_065839001.1 type IV secretory system conjugative DNA transfer family protein -
GZ986_RS10200 10546..12735 - 2190 WP_181913659.1 DUF1738 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..38770 38770


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(60-164)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 224 a.a.        Molecular weight: 25705.77 Da        Isoelectric Point: 9.2753

>T168849 WP_065839018.1 NZ_CP059442:c7645-6974 [Campylobacter fetus]
MIDKVLKFLDDGIPKNDFDRQLLASNLVGATNLIELNKREREITLKKQLKLQLNPIKGNFDYQHLKDIHKALFEDVYTWA
GKDRNDMKIYGFMSKGNSVFCAGEYIPKEAEKIFTNLQNQNYFKECKDLNHFAKDIANFMSDLNALHPFREGNGRIQRIF
INQLAKNAGYKLDLNLIPKEKIITASIEAMECKNTKLEALIKTNLKSFKQNLEKENALGLSLC

Download         Length: 672 bp

>T168849 NZ_CP076245:4116384-4116602 [Escherichia coli O157:H7]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9009.20 Da        Isoelectric Point: 4.4547

>AT168849 WP_046037523.1 NZ_CP059442:c7874-7638 [Campylobacter fetus]
MTYPEVHSLEESLAILKKYKDDVSKKDYEEIKSTICGHAIENMFANEKDVIDMIKIAKNEANADEIIAEYKKEWGIND

Download         Length: 237 bp

>AT168849 NZ_CP076245:4115984-4116358 [Escherichia coli O157:H7]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACTCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7D7Q4U4

Antitoxin

Source ID Structure
AlphaFold DB A0A7D7Q4X0

References